Evidence map›Paper›PMID 38877299›Full record

ArticleCommunications biology2024

Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype.

Bryony A Curry, Aimee L Drane, Rebeca Atencia, Yedra Feltrer, Thalita Calvi, Ellie L Milnes, Sophie Moittié, Annika Weigold, Tobias Knauf-Witzens, Arga Sawung Kusuma and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bryony A CurryCentre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, V1V 1V7, Canada.
Aimee L DraneInternational Primate Heart Project, Cardiff Metropolitan University, Cyncoed Road, Cardiff, CF23 6XD, UK. a.l.drane@swansea.ac.uk.ORCID 0000-0002-5208-917X
Rebeca AtenciaJane Goodall Institute, Tchimpounga Chimpanzee Rehabilitation Centre, Pointe-Noire, Republic of Congo.
Yedra FeltrerInternational Primate Heart Project, Cardiff Metropolitan University, Cyncoed Road, Cardiff, CF23 6XD, UK.
Thalita CalviChimfunshi Wildlife Orphanage, Solwesi Road, Chingola, Zambia.
Ellie L MilnesWildlife Health, Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK.ORCID 0000-0002-7797-2217
Sophie MoittiéTacugama Chimpanzee Sanctuary, Congo Dam Access Road, Freetown, Sierra Leone.
Annika WeigoldWilhelma Zoological-Botanical Gardens, Wilhelma 13, Stuttgart, 70376, Germany.
Tobias Knauf-WitzensWilhelma Zoological-Botanical Gardens, Wilhelma 13, Stuttgart, 70376, Germany.
Arga Sawung KusumaBorneo Orangutan Survival Foundation, Central Kalimantan Orangutan Reintroduction Project at Nyaru Menteng, Jalan Cilik Riwut km 28, Palangkaraya, 73111, Central Kalimantan, Indonesia.
Glyn HowatsonFaculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, NE1 8ST, UK.
Christopher PalmerBiological Science, University of New South Wales, Sydney, NSW, 2052, Australia.
Mike R StembridgeCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, CF23 6XD, UK.
John E GorzynskiDepartment of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID 0000-0002-9034-9016
Neil D EvesCentre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, V1V 1V7, Canada.
Tony G DawkinsCentre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, V1V 1V7, Canada.ORCID 0000-0001-5203-135X
Rob E ShaveCentre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, V1V 1V7, Canada. rob.shave@ubc.ca.ORCID 0000-0002-0283-037X

Funding

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada) GR017741
6 · The paper itself

Abstract

Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon, using 2D echocardiography, to gain insight into the evolution of the human heart. We present compelling evidence that the human LV has diverged away from a more trabeculated phenotype present in all other great apes, towards a ventricular wall with proportionally greater compact myocardium, which was corroborated by post-mortem chimpanzee (Pan troglodytes) hearts. Speckle-tracking echocardiographic analyses identified a negative curvilinear relationship between the degree of trabeculation and LV systolic twist, revealing lower rotational mechanics in the trabeculated non-human great ape LV. This divergent evolution of the human heart may have facilitated the augmentation of cardiac output to support the metabolic and thermoregulatory demands of the human ecological niche.

Indexed as

Heart VentriclesHominidaePhenotypeAnimalsBiological EvolutionEchocardiographyFemaleHumansMalePan troglodytes

Identifiers

PMID38877299
PMCPMC11178792

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.