Evidence map›Paper›PMID 38877781›Full record

ArticleActa biochimica et biophysica Sinica2024

Hepatitis E virus infection upregulates ING5 expression

Wanqiu Zhao, Yueping Xia, Tengyuan Li, Huichan Liu, Guo Zhong, Dongxue Chen, Wenhai Yu, Yunlong Li, Fen Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Research Progress on Hepatitis E Virus Culture.Pathogens (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wanqiu ZhaoMedical Faculty, Kunming University of Science and Technology, Kunming 650500, China.
Yueping XiaMedical Faculty, Kunming University of Science and Technology, Kunming 650500, China.
Tengyuan LiMedical Faculty, Kunming University of Science and Technology, Kunming 650500, China.
Huichan LiuMedical Faculty, Kunming University of Science and Technology, Kunming 650500, China.
Guo ZhongMedical Faculty, Kunming University of Science and Technology, Kunming 650500, China.
Dongxue ChenMedical Faculty, Kunming University of Science and Technology, Kunming 650500, China.
Wenhai YuInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650038, China.
Yunlong LiMedical Faculty, Kunming University of Science and Technology, Kunming 650500, China.
Fen HuangMedical Faculty, Kunming University of Science and Technology, Kunming 650500, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis E virus (HEV) is the major pathogen of viral hepatitis. Immunocompromised individuals infected by HEV are prone to chronic hepatitis and increase the risk of hepato-cellular carcinoma (HCC). Inhibitor of growth family member 5 (ING5) is a tumor suppressor that is expressed at low levels in cancer tumors or cells. However, the underlying relationship between ING5 and HEV infection is unclear. In the present study, acute and chronic HEV animal models are used to explore the interaction between ING5 and HEV. Notably, the expression of ING5 is significantly increased in both the livers of acute HEV-infected BALB/c mice and chronic HEV-infected rhesus macaques. In addition, the relationship between HEV infection and ING5 expression is further identified in human hepatoma (HepG-2) cells. In conclusion, HEV infection strongly upregulates ING5 expression both

Indexed as

Hepatitis EMacaca mulattaMice, Inbred BALB CTumor Suppressor ProteinsUp-RegulationAnimalsDisease Models, AnimalHepatitis E virusHep G2 CellsHumansLiverMiceTranscription FactorsING5 protein, humanTranscription FactorsTumor Suppressor ProteinsBALB/c miceHepG-2HEVING5rhesus macaques

Identifiers

PMID38877781
PMCPMC11532201

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.