Evidence map›Paper›PMID 38878921›Full record

ArticleInternational journal of biological macromolecules2024

Fine-tuning pH sensor H98 by remote essential residues in the hydrogen-bond network of mTASK-3.

Xueming Fan, Yifei Ye, Aakash Saha, Li Peng, Chinmai Pindi, Qi Wang, Linghui Yang, Jin Liu, Xiangdong Tang, Giulia Palermo and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological macromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xueming FanDepartment of Pain Management, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China; Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610000, China.
Yifei YeLaboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610000, China; Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Aakash SahaDepartment of Bioengineering, University of California Riverside, 900 University Avenue, Riverside, CA 92521, United States.
Li PengLaboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610000, China.
Chinmai PindiDepartment of Bioengineering, University of California Riverside, 900 University Avenue, Riverside, CA 92521, United States.
Qi WangLaboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610000, China; Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Linghui YangLaboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610000, China.
Jin LiuLaboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610000, China; Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Xiangdong TangSleep Medicine Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China; Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China; State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Giulia PalermoDepartment of Bioengineering, University of California Riverside, 900 University Avenue, Riverside, CA 92521, United States.
Jiayu LiaoDepartment of Bioengineering, University of California Riverside, 900 University Avenue, Riverside, CA 92521, United States; Huaxi-Cal Research Center for Predictive Intervention Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610000, China.
Tingting XuGuangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guizhou, Guangdong 510530, China.
Yongzhi LuGuangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong 510005, China. Electronic address: lu_yongzhi@gzlab.ac.cn.
Guizhi DuLaboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610000, China; Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: duguizhi@scu.edu.cn.

Funding

Investigating the metal-dependent function, allostery and inhibition of CRISPR-Cas9R01GM141329 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI PALERMO, GIULIA · 2021 to 2025
$1.7M
NIGMS NIH HHS R01 GM141329
6 · The paper itself

Abstract

TASK-3 generates a background K

Indexed as

Hydrogen BondingMolecular Dynamics SimulationPotassium Channels, Tandem Pore DomainAnimalsHumansHydrogen-Ion ConcentrationMutationPotassium Channels, Tandem Pore DomainH98Hydrogen-bond networkmTASK-3pH sensitivityRemote tuningS31

Identifiers

PMID38878921
PMCPMC11583903

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.