Evidence map›Paper›PMID 38879520›Full record

Trial reportBMC research notes2024

Lower levels of plasma syndecan-4 are associated with loss of body weight and fat-free mass after bariatric surgery.

Catia Martins, Marthe Isaksen Aukan, Maria De Luca

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC research notes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04051190 (Effects of Diet-induced Weight Loss Versus Sleeve Gastrectomy and Gastric Bypass on Homeostatic and Hedonic Appetite Markers and Gut Microbiota), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04051190 nacompletednot on this map

Effects of Diet-induced Weight Loss Versus Sleeve Gastrectomy and Gastric Bypass on Homeostatic and Hedonic Appetite Markers and Gut Microbiota

TypeinterventionalSponsorNorwegian University of Science and TechnologyRan2019 to 2022Enrolled54ConditionsObesityArmsVLED group, Sleeve Gastrectomy group, Gastric Bypass group
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Catia MartinsDepartment of Nutrition Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Marthe Isaksen AukanObesity Research Group, Department of Clinical and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Maria De LucaDepartment of Nutrition Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL, USA. mdeluca2@uab.edu.

Funding

UAB Nutrition Obesity Research Center (NORC)P30DK056336 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2000 to 2025
$6.0M
NIA NIH HHS AG063197NIA NIH HHS R21 AG063197NIDDK NIH HHS P30 DK056336
6 · The paper itself

Abstract

objectiveBariatric surgery induces a significant loss of both fat mass (FM) and fat-free mass (FFM). The proteoglycan receptor syndecan-4 (SDC4) plays a crucial role in adipose tissue and skeletal muscle functions. Thus, this study was performed (i) to assess plasma SDC4 levels after both Sleeve Gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB) surgeries, and (ii) to explore potential associations with changes in body composition variables.

resultsTwenty-six patients (17 females) with severe obesity underwent SG (n = 13) or RYGB (n = 13) and were followed up to 1 year (1Y). Body weight, FM, FFM, and SCD4 were measured at baseline (BL), and at week 11 (W11) and 1Y after surgery. Independently of procedure, there was a significant body weight loss at W11, with an average FM and FFM reduction of 13.7 ± 0.6 kg and 5.3 ± 0.5 kg, respectively. Participants continued to lose weight afterwards, with a total weigth loss of 38.2 ± 1.5 kg at 1Y. No associations were found at BL between SDC4 levels and any anthropometric variable; however, SDC4 levels were lower than BL at both W11 and 1Y, independently of type of surgery. Additionally, changes in SDC4 between BL and 1Y were positively correlated with weight and FFM loss during the same period.

trial registrationClinicalTrials.gov NCT04051190 on 09/08/2019.

Indexed as

Bariatric SurgerySyndecan-4Weight LossAdipose TissueAdultBody CompositionFemaleGastrectomyGastric BypassHumansMaleMiddle AgedObesity, MorbidSDC4 protein, humanSyndecan-4Bariatric procedureExtracellular matrixHeparan sulfate proteoglycansSevere obesitySkeletal muscle

Identifiers

PMID38879520
PMCPMC11179341

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.