Evidence map›Paper›PMID 38879526›Full record

ArticleClinical epigenetics2024

DNA methylation in peripheral blood is associated with renal aging and renal function decline: a national community study.

Po-Lung Yang, Tai-Shuan Lai, Yu-Hsiang Chou, Liang-Chuan Lai, Shuei-Liong Lin, Yung-Ming Chen

Abstract read
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In one paragraph

Article in Clinical epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The Aging Kidney and Acute Kidney Injury.Journal of the American Society of Nephrology : JASN · 2026
    Review
  2. Article
  3. NRF2 Dysregulation and Therapeutic Insights Across Chronic Kidney Diseases.International journal of molecular sciences · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Po-Lung Yang *Department of Geriatrics and Gerontology, National Taiwan University Hospital College of Medicine, National Taiwan University, Taipei, Taiwan.
Tai-Shuan Lai *Renal Division, Department of Internal Medicine, National Taiwan University, College of Medicine, No. 1, Jen-Ai Road, Section 1, Taipei, 100, Taiwan.
Yu-Hsiang ChouRenal Division, Department of Internal Medicine, National Taiwan University, College of Medicine, No. 1, Jen-Ai Road, Section 1, Taipei, 100, Taiwan. chouyuhsiang@ntuh.gov.tw.
Liang-Chuan LaiGraduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Shuei-Liong LinRenal Division, Department of Internal Medicine, National Taiwan University, College of Medicine, No. 1, Jen-Ai Road, Section 1, Taipei, 100, Taiwan.
Yung-Ming ChenRenal Division, Department of Internal Medicine, National Taiwan University, College of Medicine, No. 1, Jen-Ai Road, Section 1, Taipei, 100, Taiwan.

Funding

National Health Research Institutes NHRI-EX113-11316SCNational Science and Technology Council 108-2314-B-002 -060Taipei Medical University 111-TMU021
6 · The paper itself

Abstract

backgroundOlder patients are at risk for acute kidney injury and chronic kidney disease. Age-related increases in DNA methylation at CpG islands have been linked to aging-related diseases like cancer and cardiovascular disease, but the exact causal relationship between methylation in renal aging and other kidney diseases remains unclear. This study aimed to elucidate the methylation status of peripheral blood mononuclear cells (PBMCs) in the Asian population. Using human whole blood DNA methylation analysis from the Taiwan Biobank, we included participants with both whole blood genome-wide methylation data and follow-up data on serum creatinine. We investigated hyper- and hypomethylated genes in comparison of participants with higher and lower estimated glomerular filtration (eGFR) decline rate in overall cohort as well as in comparison of old and young participants in subgroup of participants with higher eGFR decline rate. Common genes and signaling pathways in both comparative analyses were identified.

resultsAmong 1587 participants in the analysis, 187 participants had higher eGFR decline rate. According to the comparison of methylation in participants with different eGFR declines and at different ages, respectively, we identified common hypermethylated genes, including DNMT3A and GGACT, as well as hypomethylated genes such as ARL6IP5, CYB5D1, BCL6, RPRD2, ZNF451, and MIAT in both participants with higher eGFR decline and those of older age. We observed associations between the methylation status of signaling pathways and aging as well as renal function decline. These pathways notably included autophagy, p38 mitogen-activated protein kinases, and sirtuins, which were associated with autophagy process and cytokine production.

conclusionsThrough methylation analysis of PBMCs, we identified genes and signaling pathways which could play crucial roles in the interplay of renal aging and renal function decline. These findings contribute to the development of novel biomarkers for identifying at-risk groups and even for therapeutic agent discovery.

Indexed as

AgingCpG IslandsDNA MethylationGlomerular Filtration RateAdultAgedEpigenesis, GeneticFemaleGenome-Wide Association StudyHumansKidneyLeukocytes, MononuclearMaleMiddle AgedRenal Insufficiency, ChronicTaiwanChronic kidney diseaseDNA methylationEstimated glomerular filtration ratePeripheral blood mononuclear cellRenal aging

Identifiers

PMID38879526
PMCPMC11180394

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.