ArticleNature communications2024
Intra-islet α-cell Gs signaling promotes glucagon release.
Erratum issuedAbstract read
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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11citing papers in PubMed
–field-weighted citation impact
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Who cites it
11 citing papers in PubMed.
- One Week Exposure to a Somatostatin Receptor 2 Antagonist (SSTR2a) Enhances Glucagon Counterregulation to Insulin-Induced Hypoglycaemia and Does Not Worsen Glycemia in a Male Rat Model of Insulin-Requiring Type 2 Diabetes.Diabetes, obesity & metabolism · 2026Article
- Metabolic reprogramming drives pancreatic β cell neogenesis from α cells.Nature chemical biology · 2026Article
- Overview of the DREADDs chemogenetics and the patent landscape of their actuators.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
- Multi-omics dissection of heat stress reveals CIITA as a central regulator of metabolic thermotolerance in cattle (Bos taurus).Communications biology · 2026Article
- CBP/p300 is critical for the expansion and maintenance of functional pancreatic α cell mass.Nature communications · 2026Article
- Genome-wide cell type-specific and sex-specific transcriptional dysregulation in the islet of Langerhans underlies islet dysfunction in Down syndrome-related diabetes.bioRxiv : the preprint server for biology · 2026Article
- Gαs defines the fundamental coupling mechanism of insulin secretion.Journal of diabetes investigation · 2026Article
- Acute activation of Gq-signaling in islet macrophages inhibits β-cell insulin secretion through AMPK-sphingolipid axis.bioRxiv : the preprint server for biology · 2025Article
- Type 2 Diabetes and the Multifaceted Gut-X Axes.Nutrients · 2025Review
- Acute Inhibition of Adipose Triglyceride Lipase by NG497 Dysregulates Insulin and Glucagon Secretion From Human Islets.Endocrinology · 2025Article
- Commentary on "Intra-islet α-cell Gs signaling promotes glucagon release".Journal of diabetes investigation · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors.
Liu LiuMolecular Signaling Section, LBC, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA. liu.liu@nih.gov.ORCID http://orcid.org/0000-0002-8751-7103
Kimberley ElDuke Molecular Physiology Institute, Duke University, Durham, NC, 27701, USA.ORCID http://orcid.org/0000-0002-5550-1684
Diptadip DattaroyMolecular Signaling Section, LBC, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
Luiz F BarellaMolecular Signaling Section, LBC, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0003-2211-3842
Yinghong CuiMolecular Signaling Section, LBC, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
Sarah M GrayDuke Molecular Physiology Institute, Duke University, Durham, NC, 27701, USA.
Carla GuedikianDuke Molecular Physiology Institute, Duke University, Durham, NC, 27701, USA.ORCID http://orcid.org/0009-0005-8499-3955
Min ChenMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
Lee S WeinsteinMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
Emily KnuthDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Erli JinDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Matthew J MerrinsDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Jeffrey RomanInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Klaus H KaestnerInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Nicolai DolibaInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jonathan E CampbellDuke Molecular Physiology Institute, Duke University, Durham, NC, 27701, USA.ORCID http://orcid.org/0000-0003-4358-6331
Jürgen WessMolecular Signaling Section, LBC, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA. jurgenw@niddk.nih.gov.ORCID http://orcid.org/0000-0003-0818-1232
Funding
Univ of Pennsylvania Diabetes Endocrinology Res CTRP30DK019525 · UNIVERSITY OF PENNSYLVANIA · 1986 to 2025
$10.9MRole of G protein-coupled receptors in regulating glucose and energy homeostasisZIADK075021 · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2025 to 2025
$2.1MENGINEERED GLUCOSE METABOLISM IN INSULIN-SECRETING CELLSR01DK046492 · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · 1993 to 2025
$1.5MEngineered Glucose Metabolism in Insulin Secreting CellsR37DK046492 · DUKE UNIVERSITY · 2003 to 2005
$1.2MMitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.R01DK127637 · YALE UNIVERSITY · 2025 to 2025
$685kMetabolic Functions of Pyruvate Kinase M2 in Pancreatic Beta-cellsR01DK113103 · UNIVERSITY OF WISCONSIN-MADISON · 2025 to 2025
$485kRole of the Gnas Gene in Metabolic RegulationZIADK043313 · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2025 to 2025
$182kRole of Gs-alpha in central regulation of energy and glucose metabolismZIADK043315 · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2025 to 2025
$182kRole of Gs-alpha in pancreatic islet cell growth and functionZIADK043318 · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2025 to 2025
$182kTargeting alpha-cell GPCRs to stimulate glucagon and counter hypoglycemiaK01DK132461 · DUKE UNIVERSITY · 2025 to 2025
$106kRegulation of alpha-cell glucagon secretion by mitochondrial anaplerosis-cataplerosisF31DK134171 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Emily Knuth · 2024 to 2024
$18kMetabolic regulation of islet hormone secretion in diabetesI01BX005113 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · 2022 to 2025
–BLRD VA I01 BX005113Intramural NIH HHS ZIA DK075021NIDDK NIH HHS F31 DK134171NIDDK NIH HHS F32 DK121420NIDDK NIH HHS K01 DK132461NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK046492NIDDK NIH HHS R01 DK113103NIDDK NIH HHS R01 DK123075NIDDK NIH HHS R01 DK125353NIDDK NIH HHS R01 DK127637NIDDK NIH HHS R21 DK075021NIDDK NIH HHS R37 DK046492
Abstract
Glucagon, a hormone released from pancreatic α-cells, is critical for maintaining euglycemia and plays a key role in the pathophysiology of diabetes. To stimulate the development of new classes of therapeutic agents targeting glucagon release, key α-cell signaling pathways that regulate glucagon secretion need to be identified. Here, we focused on the potential importance of α-cell G
Indexed as
GlucagonGlucagon-Secreting CellsGTP-Binding Protein alpha Subunits, GsMice, KnockoutSignal TransductionAdenosineAnimalsIslets of LangerhansMaleMiceMice, Inbred C57BLReceptor, Adenosine A2AAdenosineGlucagonGTP-Binding Protein alpha Subunits, GsReceptor, Adenosine A2A
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What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.