Evidence map›Paper›PMID 38883839›Full record

ArticleiScience2024

Cerebrospinal fluid and plasma concentrations of the inflammatory marker soluble CD27 in a large surgical population.

Celien Tigchelaar, Janet L Cunningham, Annica J Rasmusson, Måns Thulin, Joachim Burman, Ido P Kema, Anders Larsson, Anthony R Absalom

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Celien TigchelaarDepartment of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Janet L CunninghamDepartment of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.
Annica J RasmussonDepartment of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.
Måns ThulinDepartment of Mathematics, Uppsala University, Uppsala, Sweden.
Joachim BurmanDepartment of Medical Sciences, Neurology, Uppsala University, Uppsala, Sweden.
Ido P KemaDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Anders LarssonDepartment of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
Anthony R AbsalomDepartment of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soluble CD27 (sCD27) is a potential biomarker for diseases involving immune dysfunction. As there is currently little data on cerebrospinal fluid (CSF) sCD27 concentrations in the general population we measured CSF and plasma concentrations in 486 patients (age range 18-92 years, 57% male) undergoing spinal anesthesia for elective surgery. Across the complete cohort the median [range] sCD27 concentrations were 163 [<50 to 7474] pg/mL in CSF and 4624 [1830 to >400,000] pg/mL in plasma. Plasma sCD27, age and Qalb were the factors most strongly associated with CSF sCD27 levels. Reference sCD27 concentration intervals (central 95% of values) in a sub-group without the indication of neuropsychiatric, inflammatory or systemic disease (158 patients) were <50 pg/mL - 419 pg/mL for CSF and 2344-36422 pg/mL for plasma. These data provide preliminary reference ranges that could inform future studies of the validity of sCD27 as a biomarker for neuro- and systemic inflammatory disorders.

Indexed as

Health sciencesInternal medicineMedical specialtyMedicineNeurologyNeurosurgery

Identifiers

PMID38883839
PMCPMC11179565

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.