Evidence map›Paper›PMID 38885313›Full record

ArticleThe Journal of clinical endocrinology and metabolism2024

The Association of Adiposity and RAAS With Incident Diabetes in African Americans: The Jackson Heart Study.

Divya Nedungadi, Timothy M Ayodele Adesanya, Melanie Natasha Rayan, Songzhu Zhao, Amaris Williams, Guy Brock, Joshua J Joseph

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Aldosterone and Diabetes Risk: An Association in Need of Mechanistic Insights.The Journal of clinical endocrinology and metabolism · 2025
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Divya NedungadiDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43202, USA.
Timothy M Ayodele AdesanyaDepartment of Family and Community Medicine, The Ohio State University of College of Medicine, Columbus, OH 43202, USA.
Melanie Natasha RayanDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43202, USA.ORCID 0009-0005-0646-5508
Songzhu ZhaoDepartment of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, OH 43210, USA.
Amaris WilliamsDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43202, USA.
Guy BrockDepartment of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, OH 43210, USA.
Joshua J JosephDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43202, USA.ORCID 0000-0001-9169-8261

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
The Role of The Renin-Angiotensin-Aldosterone System, ARMC5, and Neprilysin in Glucose Metabolism among African AmericansK23DK117041 · NIDDK · OHIO STATE UNIVERSITY · PI JOSEPH, JOSHUA J · 2018 to 2022
$1.0M
NCATS NIH HHS UL1 TR002733NCATS NIH HHS UL1TR002733NHLBINHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INIDDK NIH HHS K23 DK117041NIDDK NIH HHS K23DK117041NIHNIMHDNIMHD NIH HHS HHSN268201800013IThe Robert Wood Johnson Foundation Harold Amos Medical Faculty Development Program 76236
6 · The paper itself

Abstract

backgroundThe renin-angiotensin-aldosterone system (RAAS) and adiposity measures are independently associated with the development of diabetes in African American adults. However, studies have not examined the combined interaction between RAAS and adiposity measures in relation to diabetes risk in African American adults.

objectiveWe examined the longitudinal association of combined RAAS and adiposity measures with incident diabetes among African American adults in the Jackson Heart Study.

methodsAfrican American adults were assessed at baseline (2000-2004) and over 12 years of follow-up. RAAS, anthropometric (waist circumference [WC], body mass index), and adipokine (adiponectin, leptin, leptin to adiponectin ratio [LAR]) measures were collected at baseline. Aldosterone, WC, and LAR were chosen as the best predictor variables. The final model, adjusting for age, sex, education, occupation, systolic blood pressure, smoking, physical activity and RAAS-altering medications, incorporated these variables and their interactions (WC*aldosterone + LAR*aldosterone) to explore their impact on incident diabetes.

resultsAmong 3219 participants without diabetes at baseline, there were 554 incident cases over a median follow-up period of 7.5 years. Aldosterone, WC, and LAR were positively associated with incident diabetes (all P < .05). A significant interaction was found between WC and aldosterone, with a greater association among individuals with lower WC. This interaction was significant in participants with prediabetes but not in those with normoglycemia. No significant interaction was found between log-LAR and aldosterone with risk of incident diabetes.

conclusionHigher aldosterone in participants is associated with greater risk of diabetes, particularly among individuals with prediabetes and lower WC.

Indexed as

AdiposityAldosteroneBlack or African AmericanRenin-Angiotensin SystemAdiponectinAdultAgedBody Mass IndexDiabetes MellitusDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHumansIncidenceLeptinLongitudinal StudiesAdiponectinAldosteroneLeptinadiponectinAfrican Americanaldosteroneleptinprediabeteswaist circumference

Identifiers

PMID38885313
PMCPMC11651680

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.