Evidence map›Paper›PMID 38887912›Full record

ReviewArtificial organs2024

The development, use, and challenges of electromechanical tissue stimulation systems.

Jie Hu, William Anderson, Emily Hayes, Ellie Annah Strauss, Jordan Lang, Josh Bacos, Noah Simacek, Helen H Vu, Owen J T McCarty, Hoyeon Kim and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Artificial organs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jie HuDepartment of Mechanical Engineering, University of Massachusetts, Lowell, Massachusetts, USA.
William AndersonDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, Newberg, Oregon, USA.
Emily HayesDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, Newberg, Oregon, USA.
Ellie Annah StraussDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, Newberg, Oregon, USA.
Jordan LangDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, Newberg, Oregon, USA.
Josh BacosDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, Newberg, Oregon, USA.
Noah SimacekDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, Newberg, Oregon, USA.
Helen H VuDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.
Owen J T McCartyDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.
Hoyeon KimDepartment of Engineering, Loyola University Maryland, Baltimore, Maryland, USA.
Youngbok Abraham KangDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, Newberg, Oregon, USA.ORCID https://orcid.org/0000-0002-8562-3797

Funding

Contact Pathway Activation on Vascular DevicesR01HL144113 · OREGON HEALTH & SCIENCE UNIVERSITY · 2025 to 2025
$721k
Characterization of Coagulation Factor-platelet Interactions: Role of FXIR01HL101972 · OREGON HEALTH & SCIENCE UNIVERSITY · 2025 to 2025
$701k
NHLBI NIH HHS R01 HL101972NHLBI NIH HHS R01 HL144113NIAID NIH HHS R01 AI157037
6 · The paper itself

Abstract

backgroundTissue stimulations greatly affect cell growth, phenotype, and function, and they play an important role in modeling tissue physiology. With the goal of understanding the cellular mechanisms underlying the response of tissues to external stimulations, in vitro models of tissue stimulation have been developed in hopes of recapitulating in vivo tissue function.

methodsHerein we review the efforts to create and validate tissue stimulators responsive to electrical or mechanical stimulation including tensile, compression, torsion, and shear.

resultsEngineered tissue platforms have been designed to allow tissues to be subjected to selected types of mechanical stimulation from simple uniaxial to humanoid robotic stain through equal-biaxial strain. Similarly, electrical stimulators have been developed to apply selected electrical signal shapes, amplitudes, and load cycles to tissues, lending to usage in stem cell-derived tissue development, tissue maturation, and tissue functional regeneration. Some stimulators also allow for the observation of tissue morphology in real-time while cells undergo stimulation. Discussion on the challenges and limitations of tissue simulator development is provided.

conclusionsDespite advances in the development of useful tissue stimulators, opportunities for improvement remain to better reproduce physiological functions by accounting for complex loading cycles, electrical and mechanical induction coupled with biological stimuli, and changes in strain affected by applied inputs.

Indexed as

Tissue EngineeringAnimalsBiomechanical PhenomenaElectric StimulationHumansStress, Mechanicalelectrical stimulationmechanical stimulationstretching systemtissue stimulation

Identifiers

PMID38887912
PMCPMC11321926

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.