Evidence map›Paper›PMID 38888693›Full record

ReviewBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2024

Natural antibiotics against antimicrobial resistance: sources and bioinspired delivery systems.

Beatriz N Guedes, Karolline Krambeck, Alessandra Durazzo, Massimo Lucarini, Antonello Santini, M Beatriz P P Oliveira, Faezeh Fathi, Eliana B Souto

Abstract readReview
In one paragraph

Review in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Microorganisms · 2026
    Article
  3. Review
  4. RSC advances · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Phytochemical Profile and Bioactive Potential ofCurrent issues in molecular biology · 2026
    Article
  9. Review
  10. Biocompatible Thin Films Deposited by Laser Techniques.Materials (Basel, Switzerland) · 2026
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Mechanism, Efficacy, and Safety of Natural Antibiotics.Antibiotics (Basel, Switzerland) · 2025
    Review
  18. Article
  19. Biochemistry and biophysics reports · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Beatriz N GuedesLaboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Porto, 4050-313, Portugal.
Karolline KrambeckHealth Sciences School, Guarda Polytechnic Institute, Rua da Cadeia, Guarda, 6300-035, Portugal.
Alessandra DurazzoCREA-Research Centre for Food and Nutrition, Via Ardeatina 546, Rome, 00178, Italy.
Massimo LucariniCREA-Research Centre for Food and Nutrition, Via Ardeatina 546, Rome, 00178, Italy.
Antonello SantiniDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, Napoli, 80131, Italy.
M Beatriz P P OliveiraREQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 280, Porto, 4050-313, Portugal.
Faezeh FathiREQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 280, Porto, 4050-313, Portugal. ffathi@ff.up.pt.
Eliana B SoutoLaboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Porto, 4050-313, Portugal. ebsouto@ff.up.pt.ORCID http://orcid.org/0000-0002-9737-6017

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current burden associated to multidrug resistance, and the emerging superbugs, result in a decreased and even loss of antibiotic efficacy, which poses significant challenges in the treatment of infectious diseases. This situation has created a high demand for the discovery of novel antibiotics that are both effective and safe. However, while antibiotics play a crucial role in preventing and treating diseases, they are also associated with adverse effects. The emergence of multidrug-resistant and the extensive appearance of drug-resistant microorganisms, has become one of the major hurdles in healthcare. Addressing this problem will require the development of at least 20 new antibiotics by 2060. However, the process of designing new antibiotics is time-consuming. To overcome the spread of drug-resistant microbes and infections, constant evaluation of innovative methods and new molecules is essential. Research is actively exploring alternative strategies, such as combination therapies, new drug delivery systems, and the repurposing of existing drugs. In addition, advancements in genomic and proteomic technologies are aiding in the identification of potential new drug targets and the discovery of new antibiotic compounds. In this review, we explore new sources of natural antibiotics from plants, algae other sources, and propose innovative bioinspired delivery systems for their use as an approach to promoting responsible antibiotic use and mitigate the spread of drug-resistant microbes and infections.

Indexed as

Anti-Bacterial AgentsDrug Delivery SystemsAnimalsBacteriaBacterial InfectionsBiological ProductsDrug Resistance, Multiple, BacterialHumansAnti-Bacterial AgentsBiological ProductsAlgae-based antibioticsAntimicrobial resistanceBioinspired delivery systemsNatural antibioticsPlant-based antibiotics

Identifiers

PMID38888693
PMCPMC11405619

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.