Evidence map›Paper›PMID 38889145›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

CaMKII autophosphorylation is the only enzymatic event required for synaptic memory.

Xiumin Chen, Qixu Cai, Jing Zhou, Samuel J Pleasure, Howard Schulman, Mingjie Zhang, Roger A Nicoll

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  9. Widely Used CaMKII Regulatory Segment Mutations Cause Tight Actinin Binding and Dendritic Spine Enlargement in Unstimulated Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Xiumin ChenDepartment of Neurology and Institute of Neuroscience of Soochow University, Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Qixu CaiDivision of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Jing ZhouDepartment of Neurology, University of California, San Francisco, CA 94158.
Samuel J PleasureDepartment of Neurology, University of California, San Francisco, CA 94158.
Howard SchulmanDepartment of Pharmacology, Stanford University School of Medicine, Stanford, CA.
Mingjie ZhangDivision of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Roger A NicollDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158.

Funding

The synaptic cleft and glutamate receptor traffickingR01MH117139 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NICOLL, ROGER A · 2018 to 2022
$2.9M
NMDA receptors and callosal circuitry: development and molecular mechanismsR01MH119435 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PLEASURE, SAMUEL JEREMY · 2020 to 2023
$1.6M
NIMH NIH HHS R01 MH117139NIMH NIH HHS R01 MH119435
6 · The paper itself

Abstract

Ca

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase Type 2Long-Term PotentiationMemoryReceptors, N-Methyl-D-AspartateSynapsesAnimalsMicePhosphorylationRatsCalcium-Calmodulin-Dependent Protein Kinase Type 2NR2B NMDA receptorReceptors, N-Methyl-D-AspartateCaMKIICaMKII autophosphorylationdownstream kinase activityLTPsynaptic memory

Identifiers

PMID38889145
PMCPMC11214084

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.