Evidence map›Paper›PMID 38889727›Full record

ArticleCell2024

The genomic and cellular basis of biosynthetic innovation in rove beetles.

Sheila A Kitchen, Thomas H Naragon, Adrian Brückner, Mark S Ladinsky, Sofia A Quinodoz, Jean M Badroos, Joani W Viliunas, Yuriko Kishi, Julian M Wagner, David R Miller and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Sheila A KitchenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Thomas H NaragonDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Adrian BrücknerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Mark S LadinskyDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Sofia A QuinodozDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Jean M BadroosDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Joani W ViliunasDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Yuriko KishiDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Julian M WagnerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
David R MillerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Mina YousefelahiyehDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Igor A AntoshechkinDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
K Taro EldredgeMuseum of Zoology, University of Michigan, Ann Arbor, MI 48109, USA.
Stacy PirroIridian Genomes, 613 Quaint Acres Dr., Silver Spring, MD 20904, USA.
Mitchell GuttmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Steven R DavisDivision of Invertebrate Zoology, American Museum of Natural History, New York, NY 10024, USA.
Matthew L AardemaDepartment of Biology, Montclair State University, Montclair, NJ 07043, USA.
Joseph ParkerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: joep@caltech.edu.

Funding

A neuroethological model of sensorimotor processing in animal-animal interactionsR34NS118470 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI PARKER, JOSEPH · 2020 to 2020
$749k
NINDS NIH HHS R34 NS118470
6 · The paper itself

Abstract

How evolution at the cellular level potentiates macroevolutionary change is central to understanding biological diversification. The >66,000 rove beetle species (Staphylinidae) form the largest metazoan family. Combining genomic and cell type transcriptomic insights spanning the largest clade, Aleocharinae, we retrace evolution of two cell types comprising a defensive gland-a putative catalyst behind staphylinid megadiversity. We identify molecular evolutionary steps leading to benzoquinone production by one cell type via a mechanism convergent with plant toxin release systems, and synthesis by the second cell type of a solvent that weaponizes the total secretion. This cooperative system has been conserved since the Early Cretaceous as Aleocharinae radiated into tens of thousands of lineages. Reprogramming each cell type yielded biochemical novelties enabling ecological specialization-most dramatically in symbionts that infiltrate social insect colonies via host-manipulating secretions. Our findings uncover cell type evolutionary processes underlying the origin and evolvability of a beetle chemical innovation.

Indexed as

ColeopteraAnimalsBenzoquinonesEvolution, MolecularGenome, InsectGenomicsPhylogenySymbiosisTranscriptomeBenzoquinonesquinonebeetlesbiosynthesiscell type evolutionDalotiagene expression programsgenomicskey innovationsStaphylinidae

Identifiers

PMID38889727
PMCPMC11246231

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.