Evidence map›Paper›PMID 38890008›Full record

ArticleHIV medicine2024

Clinically recognized sleep disorders in people living with HIV.

Jennifer O Lam, Craig E Hou, Stacey Alexeeff, Tory Levine, Varada Sarovar, Alexandra N Lea, Verena E Metz, Michael A Horberg, Derek D Satre, Michael J Silverberg

Abstract read
In one paragraph

Article in HIV medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer O LamDivision of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.ORCID 0000-0001-5650-4310
Craig E HouSouth San Francisco Medical Center, Kaiser Permanente Northern California, South San Francisco, California, USA.
Stacey AlexeeffDivision of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.
Tory LevineDivision of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.
Varada SarovarDivision of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.
Alexandra N LeaDivision of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.ORCID 0000-0001-6194-699X
Verena E MetzDivision of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.
Michael A HorbergDepartment of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California, USA.
Derek D SatreDivision of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.
Michael J SilverbergDivision of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.ORCID 0000-0001-9322-1395

Funding

2/3 COMpAAAS Tripartite: ART-CC, KP, and VAU01AA026230 · NIAAA · KAISER FOUNDATION RESEARCH INSTITUTE · PI SATRE, DEREK D, SILVERBERG, MICHAEL J · 2017 to 2021
$3.0M
Electronic Health Record-Based Dementia Prediction for HIV Primary CareK01AI157849 · NIAID · KAISER FOUNDATION RESEARCH INSTITUTE · PI LAM, JENNIFER · 2021 to 2025
$713k
Improving Alcohol and Drug Services for Older AdultsK23AA015411 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SATRE, DEREK D · 2005 to 2009
$684k
National Institute of Allergy and Infectious Diseases K01AI157849NIAAA NIH HHS K23 AA015411NIAAA NIH HHS U01 AA026230NIAAA NIH HHS U01AA026230NIAID NIH HHS K01 AI157849
6 · The paper itself

Abstract

objectiveDespite recognition that people with HIV (PWH) are more vulnerable to sleep issues, there is limited understanding of clinically recognized sleep disorders in this population. Our objective was to evaluate the full spectrum of sleep disorder types diagnosed among PWH in care.

methodsWe conducted a retrospective cohort study of PWH, and a comparator group of people without HIV (PWoH), in a large healthcare system. The incidence of clinically diagnosed sleep disorders was calculated using Poisson regression for three outcomes: any type of sleep disorder, insomnia, and sleep apnea. Incidence was compared between PWH and PWoH by computing the adjusted incidence rate ratio (aIRR), accounting for sleep disorder risk factors. Comparisons to PWoH were made for all PWH combined, then with PWH stratified by HIV management status (well-managed HIV defined as being on antiretroviral therapy, HIV RNA <200 copies/mL, and CD4 count ≥500 cells/μL).

resultsThe study included 9076 PWH and 205 178 PWoH (mean age 46 years, 90% men). Compared with PWoH, sleep disorder incidence was greater among PWH overall [aIRR = 1.19, 95% confidence interval (CI): 1.12-1.26], particularly for insomnia (aIRR = 1.56, 95% CI: 1.45-1.67). Sleep apnea incidence was lower among PWH (aIRR = 0.90, 95% CI: 0.84-0.97). In HIV management subgroups, PWH without well-managed HIV had lower sleep apnea incidence (vs. PWoH: aIRR = 0.79, 95% CI: 0.70-0.89) but PWH with well-managed HIV did not (vs. PWoH: aIRR = 0.97, 95% CI: 0.89-1.06).

conclusionsPWH have high sleep disorder incidence, and insomnia is the most common clinical diagnosis. Lower sleep apnea incidence among PWH may reflect underdiagnosis in those with sub-optimally treated HIV and will be important to investigate further.

Indexed as

HIV InfectionsSleep Wake DisordersAdultFemaleHumansIncidenceMaleMiddle AgedRetrospective StudiesRisk FactorsSleep Apnea SyndromesSleep Initiation and Maintenance Disorderscomorbidityepidemiologyinsomniaprimary caresleepsleep apnea

Identifiers

PMID38890008
PMCPMC11456391

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.