Evidence map›Paper›PMID 38890406›Full record

ArticleScientific reports2024

Sex differences in social brain neural responses in autism: temporal profiles of configural face-processing within data-driven time windows.

Teresa Del Bianco, Meng-Chuan Lai, Luke Mason, Mark H Johnson, Tony Charman, Eva Loth, Tobias Banaschewski, Jan Buitelaar, Declan G M Murphy, Emily J H Jones and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Untangling Sex and Gender Differences in Impression Management and Associated Autism Features in French Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Teresa Del BiancoCentre for Brain and Cognitive Development, Henry Wellcome Building, Birkbeck University of London, Malet Street, London, WC1E 7HX, UK. t.delbianco@bbk.ac.uk.ORCID 0000-0002-7162-0042
Meng-Chuan LaiMargaret and Wallace McCain Centre for Child, Youth & Family Mental Health and Azrieli Adult Neurodevelopmental Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0002-9593-5508
Luke MasonCentre for Brain and Cognitive Development, Henry Wellcome Building, Birkbeck University of London, Malet Street, London, WC1E 7HX, UK.
Mark H JohnsonDepartment of Psychology, University of Cambridge, Cambridge, UK.
Tony CharmanInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0003-1993-6549
Eva LothInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Tobias BanaschewskiCentral Institute of Mental Health, Mannheim, Germany.ORCID 0000-0003-4595-1144
Jan BuitelaarDonders Center of Medical Neurosciences, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0001-8288-7757
Declan G M MurphyInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0002-6664-7451
Emily J H JonesCentre for Brain and Cognitive Development, Henry Wellcome Building, Birkbeck University of London, Malet Street, London, WC1E 7HX, UK.ORCID 0000-0001-5747-9540
AIMS-2-TRIALS LEAP Team

Funding

Innovate UK MR/S036423/1Innovative Medicines Initiative (IMI) 777394Medical Research Council MR/S036423/1RCUK | Medical Research Council (MRC) MR/K021389/1RCUK | Medical Research Council (MRC) MR/T003057/1
6 · The paper itself

Abstract

Face-processing timing differences may underlie visual social attention differences between autistic and non-autistic people, and males and females. This study investigates the timing of the effects of neurotype and sex on face-processing, and their dependence on age. We analysed EEG data during upright and inverted photographs of faces from 492 participants from the Longitudinal European Autism Project (141 neurotypical males, 76 neurotypical females, 202 autistic males, 73 autistic females; age 6-30 years). We detected timings of sex/diagnosis effects on event-related potential amplitudes at the posterior-temporal channel P8 with Bootstrapped Cluster-based Permutation Analysis and conducted Growth Curve Analysis (GCA) to investigate the timecourse and dependence on age of neural signals. The periods of influence of neurotype and sex overlapped but differed in onset (respectively, 260 and 310 ms post-stimulus), with sex effects lasting longer. GCA revealed a smaller and later amplitude peak in autistic female children compared to non-autistic female children; this difference decreased in adolescence and was not significant in adulthood. No age-dependent neurotype difference was significant in males. These findings indicate that sex and neurotype influence longer latency face processing and implicates cognitive rather than perceptual processing. Sex may have more overarching effects than neurotype on configural face processing.

Indexed as

Autistic DisorderBrainElectroencephalographyAdolescentAdultChildEvoked PotentialsFacial RecognitionFemaleHumansMaleSex CharacteristicsYoung Adult

Identifiers

PMID38890406
PMCPMC11189412

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.