Evidence map›Paper›PMID 38891070›Full record

ArticleCells2024

KR158 Spheres Harboring Slow-Cycling Cells Recapitulate High-Grade Glioma Features in an Immunocompetent System.

Avirup Chakraborty, Changlin Yang, Jesse L Kresak, Aryeh J Silver, Diana Feier, Guimei Tian, Michael Andrews, Olusegun O Sobanjo, Ethan D Hodge, Mia K Engelbart and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Avirup ChakrabortyAdam Michael Rosen Neuro-Oncology Laboratories, Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.ORCID 0009-0001-8676-5885
Changlin YangAdam Michael Rosen Neuro-Oncology Laboratories, Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.ORCID 0000-0001-5687-600X
Jesse L KresakDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-0559-9393
Aryeh J SilverAdam Michael Rosen Neuro-Oncology Laboratories, Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.ORCID 0000-0002-7286-1497
Diana FeierAdam Michael Rosen Neuro-Oncology Laboratories, Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Guimei TianDepartment of Surgery, University of Florida, Gainesville, FL 32610, USA.
Michael AndrewsCollege of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA.
Olusegun O SobanjoAdam Michael Rosen Neuro-Oncology Laboratories, Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Ethan D HodgeAdam Michael Rosen Neuro-Oncology Laboratories, Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Mia K EngelbartAdam Michael Rosen Neuro-Oncology Laboratories, Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Jianping HuangAdam Michael Rosen Neuro-Oncology Laboratories, Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Jeffrey K HarrisonPreston A. Wells Jr. Center for Brain Tumor Therapy, University of Florida, Gainesville, FL 32608, USA.
Matthew R SarkisianPreston A. Wells Jr. Center for Brain Tumor Therapy, University of Florida, Gainesville, FL 32608, USA.
Duane A MitchellAdam Michael Rosen Neuro-Oncology Laboratories, Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Loic P DeleyrolleAdam Michael Rosen Neuro-Oncology Laboratories, Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.ORCID 0000-0002-1129-744X

Funding

Targeting CCR2-expressing myeloid cells to overcome immune checkpoint inhibitor resistance in gliomaR01NS108781 · NINDS · UNIVERSITY OF FLORIDA · PI HARRISON, JEFFREY K., MITCHELL, DUANE A. · 2018 to 2022
$1.9M
Metabolic interactions between tumor cells and the immune system in GBM: A potential Achilles heel of GBM for novel therapeuticsR01NS121075 · NINDS · UNIVERSITY OF FLORIDA · PI DELEYROLLE, LOIC PIERRE · 2022 to 2025
$1.6M
Slow cycling cell RNA based T cell therapy to prevent recurrence in GBMR21NS116578 · NINDS · UNIVERSITY OF FLORIDA · PI DELEYROLLE, LOIC PIERRE · 2021 to 2022
$419k
Optimizing CAR T therapy via metabolic engineering for thetreatment of GBMR21CA282979 · NCI · UNIVERSITY OF FLORIDA · PI DELEYROLLE, LOIC PIERRE · 2023 to 2024
$381k
National Institute of Health 1R01NS121075National Institute of Health 1R21NS116578NCI NIH HHS R21 CA282979NINDS NIH HHS R01 NS108781NINDS NIH HHS R01 NS121075NINDS NIH HHS R21 NS116578
6 · The paper itself

Abstract

Glioblastoma (GBM) poses a significant challenge in clinical oncology due to its aggressive nature, heterogeneity, and resistance to therapies. Cancer stem cells (CSCs) play a critical role in GBM, particularly in treatment resistance and tumor relapse, emphasizing the need to comprehend the mechanisms regulating these cells. Also, their multifaceted contributions to the tumor microenvironment (TME) underline their significance, driven by their unique properties. This study aimed to characterize glioblastoma stem cells (GSCs), specifically slow-cycling cells (SCCs), in an immunocompetent murine GBM model to explore their similarities with their human counterparts. Using the KR158 mouse model, we confirmed that SCCs isolated from this model exhibited key traits and functional properties akin to human SCCs. KR158 murine SCCs, expanded in the gliomasphere assay, demonstrated sphere forming ability, self-renewing capacity, positive tumorigenicity, enhanced stemness and resistance to chemotherapy. Together, our findings validate the KR158 murine model as a framework to investigate GSCs and SCCs in GBM pathology, and explore specifically the SCC-immune system communications, understand their role in disease progression, and evaluate the effect of therapeutic strategies targeting these specific connections.

Indexed as

Neoplastic Stem CellsSpheroids, CellularAnimalsBrain NeoplasmsCell Line, TumorDisease Models, AnimalGlioblastomaGliomaHumansImmunocompetenceMiceNeoplasm GradingTumor Microenvironmentcancer stem cellsglioblastomaimmunocompetent murine modelslow-cycling cellstumor heterogeneity

Identifiers

PMID38891070
PMCPMC11171638

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.