Evidence map›Paper›PMID 38892288›Full record

ArticleInternational journal of molecular sciences2024

Studies on Autophagy and Apoptosis of Fibrosarcoma HT-1080 Cells Mediated by Chalcone with Indole Moiety.

Ewelina Honkisz-Orzechowska, Olga Barczyk-Woźnicka, Maria Kaleta, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pathology, Diagnosis, and Management of Sarcoma.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ewelina Honkisz-OrzechowskaFaculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.ORCID 0000-0002-2046-4879
Olga Barczyk-WoźnickaLaboratory of Transmission Electron Microscopy, Department of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Jagiellonian University, 9 Gronostajowa Street, 30-387 Kraków, Poland.
Maria KaletaFaculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.
Jadwiga HandzlikFaculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.ORCID 0000-0002-3674-3581
Katarzyna Kieć-KononowiczFaculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.ORCID 0000-0002-6752-7443

Funding

Jagiellonian University Medical College K/DSC/005299National Science Center DEC-2021/43/B/NZ7/01938
6 · The paper itself

Abstract

This study demonstrated the anticancer efficacy of chalcones with indole moiety (MIPP, MOMIPP) in fibrosarcoma cells for the first time. The results showed that MIPP and MOMIPP reduced the viability of HT-1080 cells in a concentration-dependent manner. MOMIPP was more active than MIPP in HT-1080 cells, showing lower IC

Indexed as

ApoptosisAutophagyChalconesFibrosarcomaIndolesReactive Oxygen SpeciesAntineoplastic AgentsCell Line, TumorCell SurvivalHumansMembrane Potential, MitochondrialMitochondriaAntineoplastic AgentsChalconesindoleIndolesReactive Oxygen Speciesapoptosisautophagyfibrosarcomaindole-based chalconeLC3-IIMIPPmitochondrial membrane potentialMOMIPP

Identifiers

PMID38892288
PMCPMC11172467

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.