Evidence map›Paper›PMID 38893295›Full record

ArticleMolecules (Basel, Switzerland)2024

Anti-Inflammatory Activity of Pyrazolo[1,5-

Letizia Crocetti, Andrei I Khlebnikov, Gabriella Guerrini, Igor A Schepetkin, Fabrizio Melani, Maria Paola Giovannoni, Mark T Quinn

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Quinazolines [Molecules (Basel, Switzerland) · 2025
    Review
  3. Review
  4. Article
  5. 3,8-Disubstituted Pyrazolo[1,5-a]quinazoline as GABAInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Letizia CrocettiDipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA), Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.ORCID 0000-0003-3473-2683
Andrei I KhlebnikovKizhner Research Center, National Research Tomsk Polytechnic University, Tomsk 634050, Russia.ORCID 0000-0002-3022-4510
Gabriella GuerriniDipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA), Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.ORCID 0000-0001-6711-7965
Igor A SchepetkinDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.
Fabrizio MelaniDipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA), Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.
Maria Paola GiovannoniDipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA), Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.
Mark T QuinnDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0001-8114-5073

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Ann Therese Bertagnolli · 2012 to 2026
$60.0M
NIGMS NIH HHS P20 GM103474NIH HHS 1P20GM103474-20A1
6 · The paper itself

Abstract

Chronic inflammation contributes to a number of diseases. Therefore, control of the inflammatory response is an important therapeutic goal. To identify novel anti-inflammatory compounds, we synthesized and screened a library of 80 pyrazolo[1,5-

Indexed as

Anti-Inflammatory AgentsQuinazolinesHumansLipopolysaccharidesMolecular Docking SimulationNF-kappa BPyrazolesStructure-Activity RelationshipTHP-1 CellsAnti-Inflammatory AgentsLipopolysaccharidesNF-kappa BPyrazolesQuinazolinesanti-inflammatory compoundc-Jun N-terminal kinasemitogen-activated protein kinasemolecular dockingpharmacophore mappingpyrazolo[1,5-a]quinazoline

Identifiers

PMID38893295
PMCPMC11173647

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.