ArticleMolecules (Basel, Switzerland)2024
2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives.
Filipe Areias, Carla Correia, Ashly Rocha, Sofia Teixeira, Marián Castro, Jose Brea, Huabin Hu, Jens Carlsson, Maria I Loza, M Fernanda Proença and 1 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Filipe AreiasCentre of Chemistry of University of Minho (CQUM), Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.
Carla CorreiaCentre of Chemistry of University of Minho (CQUM), Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.
Ashly RochaCentre of Chemistry of University of Minho (CQUM), Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.
Sofia TeixeiraCentre of Chemistry of University of Minho (CQUM), Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.ORCID 0000-0002-4086-0975 Marián CastroCenter for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Avda de Barcelona, E-15782 Santiago de Compostela, Spain.ORCID 0000-0002-4732-1966 Jose BreaCenter for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Avda de Barcelona, E-15782 Santiago de Compostela, Spain.ORCID 0000-0002-5523-1979 Huabin HuScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, SE-75124 Uppsala, Sweden.
Jens CarlssonScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, SE-75124 Uppsala, Sweden.ORCID 0000-0003-4623-2977 Maria I LozaCenter for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Avda de Barcelona, E-15782 Santiago de Compostela, Spain.
M Fernanda ProençaCentre of Chemistry of University of Minho (CQUM), Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.ORCID 0000-0002-5274-1949 M Alice CarvalhoCentre of Chemistry of University of Minho (CQUM), Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.
Funding
European Regional Development Fund ERDFFEDER funds through the Operational Programme for Competitiveness Factors (COMPETE 2020), Programa Operacional de Competitividade e Internacionalização (POCI) POCI-01-0145-FEDER-031354Fundação para a Ciência e Tecnologia UID/QUI/00686/2020, UID/QUI/ 00686/2018; SFRH/BD/22270/2005; SFRH/BD/85937/2012; SFRH/BPD/ 26106/2005Rede Nacional de RMN PINFRA/22161/2016Xunta de Galicia ED431C 2022/20
6 · The paper itselfAbstract
A set of 2-aryl-9-H or methyl-6-morpholinopurine derivatives were synthesized and assayed through radioligand binding tests at human A
Indexed as
Purinergic P1 Receptor AntagonistsAdenineCHO CellsHumansMolecular StructureMorpholinesPurinesReceptors, Purinergic P1Structure-Activity RelationshipAdenineMorpholinesPurinergic P1 Receptor AntagonistsPurinesReceptors, Purinergic P12-arylpurine derivativesadenine derivativesadenosine receptor antagonistsG protein-coupled receptorsstructure-activity relationship
Identifiers
PMID38893418
PMCPMC11173536
What Socratic holds
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LicenceCC BY
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