Evidence map›Paper›PMID 38893565›Full record

ArticleMolecules (Basel, Switzerland)2024

L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed

Liangwen Chen, Guijie Chen, Tingting Gai, Xiuhong Zhou, Jinchi Zhu, Ruiyi Wang, Xuemei Wang, Yujie Guo, Yun Wang, Zhongwen Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liangwen ChenState Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences and Technology, Anhui Agricultural University, Hefei 230036, China.
Guijie ChenState Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences and Technology, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0002-6870-5360
Tingting GaiKey Laboratory of Bioresource and Environmental Biotechnology of Anhui Higher Education Institutes, School of Biological Engineering, Institute of Digital Ecology and Health, Huainan Normal University, Huainan 232001, China.
Xiuhong ZhouState Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences and Technology, Anhui Agricultural University, Hefei 230036, China.
Jinchi ZhuKey Laboratory of Bioresource and Environmental Biotechnology of Anhui Higher Education Institutes, School of Biological Engineering, Institute of Digital Ecology and Health, Huainan Normal University, Huainan 232001, China.
Ruiyi WangKey Laboratory of Bioresource and Environmental Biotechnology of Anhui Higher Education Institutes, School of Biological Engineering, Institute of Digital Ecology and Health, Huainan Normal University, Huainan 232001, China.
Xuemei WangKey Laboratory of Bioresource and Environmental Biotechnology of Anhui Higher Education Institutes, School of Biological Engineering, Institute of Digital Ecology and Health, Huainan Normal University, Huainan 232001, China.
Yujie GuoKey Laboratory of Bioresource and Environmental Biotechnology of Anhui Higher Education Institutes, School of Biological Engineering, Institute of Digital Ecology and Health, Huainan Normal University, Huainan 232001, China.
Yun WangKey Laboratory of Bioresource and Environmental Biotechnology of Anhui Higher Education Institutes, School of Biological Engineering, Institute of Digital Ecology and Health, Huainan Normal University, Huainan 232001, China.
Zhongwen XieState Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences and Technology, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0002-3080-4881

Funding

Natural Science Foundation of Anhui Province 2208085MB37the major Project of Higher Education Natural Science Research of Anhui Province 2022AH040226the major Project of Higher Education Natural Science Research of Anhui Province 2023AH051553the Open Fund of State Key Laboratory of Tea Plant Biology and Utilization SKLTOF20220129
6 · The paper itself

Abstract

L-theanine, a unique non-protein amino acid, is an important bioactive component of green tea. Previous studies have shown that L-theanine has many potent health benefits, such as anti-anxiety effects, regulation of the immune response, relaxing neural tension, and reducing oxidative damage. However, little is known concerning whether L-theanine can improve the clearance of mitochondrial DNA (mtDNA) damage in organisms. Here, we reported that L-theanine treatment increased ATP production and improved mitochondrial morphology to extend the lifespan of UVC-exposed nematodes. Mechanistic investigations showed that L-theanine treatment enhanced the removal of mtDNA damage and extended lifespan by activating autophagy, mitophagy, mitochondrial dynamics, and mitochondrial unfolded protein response (UPR

Indexed as

Caenorhabditis elegansGlutamatesLongevityMitochondriaUltraviolet RaysAdenosine TriphosphateAnimalsAutophagyCaenorhabditis elegans ProteinsDNA DamageDNA, MitochondrialMitochondrial DynamicsMitophagySignal TransductionUnfolded Protein ResponseAdenosine TriphosphateCaenorhabditis elegans ProteinsDNA, MitochondrialGlutamatestheanineC. eleganslifespanL-theaninemitochondrial DNA damageUVC

Identifiers

PMID38893565
PMCPMC11173996

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.