Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Alessandra AltomareDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.ORCID 0000-0002-9906-6098
Giovanna BaronDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.ORCID 0000-0002-9335-6318
Giulia CambiaghiDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.
Giulio FerrarioDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.ORCID 0000-0002-8583-6290
Beatrice ZoanniDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.
Larissa Della VedovaDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.ORCID 0000-0001-5818-6272
Giulio Maria FumagalliUnitech OMICs, Università degli Studi di Milano, Viale Ortles 22/4, 20139 Milan, Italy.
Sarah D'AlessandroDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Carlo Pascal 36, 20133 Milan, Italy.ORCID 0000-0001-9241-9762
Silvia ParapiniDepartment of Biomedical Sciences for Health, Università degli Studi di Milano, Via Carlo Pascal 36, 20133 Milan, Italy.ORCID 0000-0003-2079-8892
Serena VittorioDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.ORCID 0000-0001-6092-5011
Giulio VistoliDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.ORCID 0000-0002-3939-5172
Patrizia RisoDepartment of Food, Environmental and Nutritional Sciences, Università degli Studi di Milano, Via Luigi Mangiagalli 25, 20133 Milan, Italy.ORCID 0000-0002-9204-7257
Marina CariniDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.
Serena DelbueDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Via Carlo Pascal 36, 20133 Milan, Italy.ORCID 0000-0002-3199-9369
Giancarlo AldiniDepartment of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.ORCID 0000-0002-2355-6744
Funding
Regione Lombardia POR FESR 2014-2020_BANDO Call HUB Ricerca e Innovazione
6 · The paper itself
Abstract
backgroundThe viral main protease (M
methodsThe experiments focus on finding MS covalent inhibitors of M
resultsAmong the potential candidates identified, the delphinidin-3-glucoside showed the most promising results. Its antiviral activity has been confirmed in vitro on Vero E6 cells infected with SARS-CoV-2, showing a dose-dependent inhibitory effect almost comparable to the known M
conclusionsThe HRMS analytical platform described proved to be effective in identifying compounds that covalently bind M
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.