Evidence map›Paper›PMID 38895406›Full record

ArticlebioRxiv : the preprint server for biology2024

Three-dimensional chromatin mapping of sensory neurons reveals that cohesin-dependent genomic domains are required for axonal regeneration.

Ilaria Palmisano, Tong Liu, Wei Gao, Luming Zhou, Matthias Merkenschlager, Franziska Müller, Jessica Chadwick, Rebecca Toscano Rivolta, Guiping Kong, James Wd King and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Ilaria PalmisanoDepartment of Medicine, Division of Brain Sciences, Centre for Restorative Neuroscience, Imperial College London, London, W12 0NN, UK.ORCID 0000-0002-7139-8090
Tong LiuDepartment of Computer Science, University of Miami, 330M Ungar Building, 1365 Memorial Drive, Coral Gables, FL 33124-4245 Miami, FL, USA.
Wei GaoDepartment of Medicine, Division of Brain Sciences, Centre for Restorative Neuroscience, Imperial College London, London, W12 0NN, UK.
Luming ZhouDepartment of Medicine, Division of Brain Sciences, Centre for Restorative Neuroscience, Imperial College London, London, W12 0NN, UK.
Matthias MerkenschlagerMRC LMS, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.
Franziska MüllerDepartment of Medicine, Division of Brain Sciences, Centre for Restorative Neuroscience, Imperial College London, London, W12 0NN, UK.
Jessica ChadwickDepartment of Medicine, Division of Brain Sciences, Centre for Restorative Neuroscience, Imperial College London, London, W12 0NN, UK.
Rebecca Toscano RivoltaDepartment of Medicine, Division of Brain Sciences, Centre for Restorative Neuroscience, Imperial College London, London, W12 0NN, UK.
Guiping KongDepartment of Medicine, Division of Brain Sciences, Centre for Restorative Neuroscience, Imperial College London, London, W12 0NN, UK.
James Wd KingMRC LMS, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.
Ediem Al-JiburyMRC LMS, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.
Yuyang YanDepartment of Medicine, Division of Brain Sciences, Centre for Restorative Neuroscience, Imperial College London, London, W12 0NN, UK.
Alessandro CarlinoDepartment of Neuroscience, The Ohio State University, Columbus, 43210, OH, USA.
Bryce CollisonDepartment of Neuroscience, The Ohio State University, Columbus, 43210, OH, USA.
Eleonora De VitisDepartment of Neuroscience, The Ohio State University, Columbus, 43210, OH, USA.
Sree GongalaDepartment of Medicine, Division of Brain Sciences, Centre for Restorative Neuroscience, Imperial College London, London, W12 0NN, UK.
Francesco De VirgiliisDepartment of Medicine, Division of Brain Sciences, Centre for Restorative Neuroscience, Imperial College London, London, W12 0NN, UK.
Zheng WangDepartment of Computer Science, University of Miami, 330M Ungar Building, 1365 Memorial Drive, Coral Gables, FL 33124-4245 Miami, FL, USA.
Simone Di GiovanniDepartment of Medicine, Division of Brain Sciences, Centre for Restorative Neuroscience, Imperial College London, London, W12 0NN, UK.

Funding

Advanced algorithms to infer and analyze 3D genome structuresR35GM137974 · NIGMS · UNIVERSITY OF MIAMI CORAL GABLES · PI WANG, ZHENG · 2020 to 2024
$1.8M
NIGMS NIH HHS R35 GM137974
6 · The paper itself

Abstract

The in vivo three-dimensional genomic architecture of adult mature neurons at homeostasis and after medically relevant perturbations such as axonal injury remains elusive. Here we address this knowledge gap by mapping the three-dimensional chromatin architecture and gene expression programme at homeostasis and after sciatic nerve injury in wild-type and cohesin-deficient mouse sensory dorsal root ganglia neurons via combinatorial Hi-C and RNA-seq. We find that cohesin is required for the full induction of the regenerative transcriptional program, by organising 3D genomic domains required for the activation of regenerative genes. Importantly, loss of cohesin results in disruption of chromatin architecture at regenerative genes and severely impaired nerve regeneration. Together, these data provide an original three-dimensional chromatin map of adult sensory neurons in vivo and demonstrate a role for cohesin-dependent chromatin interactions in neuronal regeneration.

Indexed as

3D chromatin architectureAxon RegenerationcohesionEpigeneticsHi-C

Identifiers

PMID38895406
PMCPMC11185766

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.