ArticleJournal of epidemiology and global health2024
Elucidating the Link Between Anxiety/Depression and Alzheimer's Dementia in the Australian Imaging Biomarkers and Lifestyle (AIBL) Study.
Article in Journal of epidemiology and global health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Synergistic association of insomnia and anxiety with cognitive impairment and dementia in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Trajectories and timing of accelerated decline in specific memory domains preceding Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Exploring the relationship between methylation of the cortisol receptor genes and brain and cognitive outcomes in individuals with elevated amyloid-β.Research square · 2025Article
- The role of diet in moderating the relationship between symptoms of depression and brain amyloid load.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Development and Validation of a Tool to Predict Onset of Mild Cognitive Impairment and Alzheimer Dementia.JAMA network open · 2025Article
- Development and validation of the Florey Dementia Risk Score web-based tool to screen for Alzheimer's disease in primary care.EClinicalMedicine · 2024Article
- Understanding machine learning applications in dementia research and clinical practice: a review for biomedical scientists and clinicians.Alzheimer's research & therapy · 2024Review
- A need to integrate pharmacological management for multimorbidity into dementia guidelines in Australia.Frontiers in public health · 2024Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe associations between mood disorders (anxiety and depression) and mild cognitive impairment (MCI) or Alzheimer's dementia (AD) remain unclear.
methodsData from the Australian Imaging, Biomarker & Lifestyle (AIBL) study were subjected to logistic regression to determine both cross-sectional and longitudinal associations between anxiety/depression and MCI/AD. Effect modification by selected covariates was analysed using the likelihood ratio test.
resultsCross-sectional analysis was performed to explore the association between anxiety/depression and MCI/AD among 2,209 participants with a mean [SD] age of 72.3 [7.4] years, of whom 55.4% were female. After adjusting for confounding variables, we found a significant increase in the odds of AD among participants with two mood disorders (anxiety: OR 1.65 [95% CI 1.04-2.60]; depression: OR 1.73 [1.12-2.69]). Longitudinal analysis was conducted to explore the target associations among 1,379 participants with a mean age of 71.2 [6.6] years, of whom 56.3% were female. During a mean follow-up of 5.0 [4.2] years, 163 participants who developed MCI/AD (refer to as PRO) were identified. Only anxiety was associated with higher odds of PRO after adjusting for covariates (OR 1.56 [1.03-2.39]). However, after additional adjustment for depression, the association became insignificant. Additionally, age, sex, and marital status were identified as effect modifiers for the target associations.
conclusionOur study provides supportive evidence that anxiety and depression impact on the evolution of MCI/AD, which provides valuable epidemiological insights that can inform clinical practice, guiding clinicians in offering targeted dementia prevention and surveillance programs to the at-risk populations.
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