Evidence map›Paper›PMID 38896990›Full record

ArticlePsychoneuroendocrinology2024

Trajectory of ghrelin and PYY around a test meal in males and females with avoidant/restrictive food intake disorder versus healthy controls.

Kaitlin N Rozzell-Voss, Kendra R Becker, Nassim Tabri, Melissa J Dreier, Shirley B Wang, Megan Kuhnle, Julia Gydus, Helen Burton-Murray, Lauren Breithaupt, Franziska Plessow and 9 more

Abstract read
In one paragraph

Article in Psychoneuroendocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kaitlin N Rozzell-VossEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.
Kendra R BeckerEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative. Electronic address: krbecker@mgh.harvard.edu.
Nassim TabriDepartment of Psychology, Carleton University, Ottawa, ON, Canada; Mental Health and Well-Being Research and Training Hub, Carleton University, Ottawa, ON, Canada.
Melissa J DreierEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.
Shirley B WangEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States; Department of Psychology, Harvard University, Cambridge, MA, United States.
Megan KuhnleEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.
Julia GydusEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.
Helen Burton-MurrayEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States; Division of Gastroenterology, Department of Medicine, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.
Lauren BreithauptEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.
Franziska PlessowDepartment of Medicine, Harvard Medical School, Boston, MA, United States; Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.
Debra FrankoEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, United States.
Kristine HauserNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.
Elisa AsanzaNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.
Madhusmita MisraNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, United States; Division of Pediatric Endocrinology, Massachusetts General Hospital, Boston, MA, United States; Department of Pediatrics, Harvard Medical School, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.
Kamryn T EddyEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.
Laura HolsenDepartment of Psychiatry, Harvard Medical School, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.
Nadia MicaliDepartment of Psychiatry, University of Geneva, Switzerland; Department of Pediatrics Gynecology and Obstetrics, University of Geneva, Switzerland; GOSH Institute of Child Health, University College London, United Kingdom.
Jennifer J ThomasEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.
Elizabeth A LawsonDepartment of Medicine, Harvard Medical School, Boston, MA, United States; Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, United States; Mass General Brigham Multidisciplinary Eating Disorder Research Collaborative.

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Homeostatic and Hedonic Food Motivation Underlying Eating Disorder TrajectoriesR01MH103402 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDDY, KAMRYN T, LAWSON, ELIZABETH AUSTEN · 2014 to 2018
$3.7M
Neurobiological and Behavioral Risk Mechanisms of Youth Avoidant/Restrictive Eating TrajectoriesR01MH108595 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN, MICALI, NADIA · 2016 to 2020
$3.4M
A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional DyspepsiaK23DK131334 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BURTON MURRAY, HELEN · 2021 to 2025
$1.1M
The Role of Negative Affect in the Cognitive-Behavioral Model of Avoidant/Restrictive Food Intake Disorder: An Integrated Analysis of Neural Circuitry, Hormones, and Momentary Negative EmotionsK23MH125143 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BECKER, KENDRA R · 2021 to 2025
$1.1M
Neurobiology of avoidant/restrictive eating in youthK24MH120568 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN · 2019 to 2023
$961k
Estrogen's Neuroprotective Effects on the Brain-Barrier in Restrictive Eating DisordersK23MH127465 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Lauren Breithaupt · 2022 to 2026
$793k
Mentorship in Biobehavioral Mechanisms of Avoidant/Restrictive Food Intake DisorderK24MH135189 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI JENNIFER JOANNE THOMAS · 2023 to 2026
$747k
Reward Processing in Anorexia Nervosa and Avoidant/Restrictive Food Intake Disorder: Behavior, Hormonal Concentrations, and Brain Activation in Low-Weight Eating Disorders.F32MH111127 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BECKER, KENDRA R · 2016 to 2018
$185k
Using Real-Time Methods to Investigate Emotion Regulation as a Modifiable Target Connecting Adolescent Social Media Use and MoodF31MH136815 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI DREIER, MELISSA J. · 2024 to 2025
$86k
NCATS NIH HHS UL1 TR001102NCATS NIH HHS UL1 TR002541NIDDK NIH HHS K23 DK131334NIDDK NIH HHS P30 DK040561NIMH NIH HHS F31 MH136815NIMH NIH HHS F32 MH111127NIMH NIH HHS K23 MH125143NIMH NIH HHS K23 MH127465NIMH NIH HHS K24 MH120568NIMH NIH HHS K24 MH135189NIMH NIH HHS R01 MH103402NIMH NIH HHS R01 MH108595
6 · The paper itself

Abstract

Disruptions in appetite-regulating hormones may contribute to the development and/or maintenance of avoidant/restrictive food intake disorder (ARFID). No study has previously assessed fasting levels of orexigenic ghrelin or anorexigenic peptide YY (PYY), nor their trajectory in response to food intake among youth with ARFID across the weight spectrum. We measured fasting and postprandial (30, 60, 120 minutes post-meal) levels of ghrelin and PYY among 127 males and females with full and subthreshold ARFID (n = 95) and healthy controls (HC; n = 32). We used latent growth curve analyses to examine differences in the trajectories of ghrelin and PYY between ARFID and HC. Fasting levels of ghrelin did not differ in ARFID compared to HC. Among ARFID, ghrelin levels declined more gradually than among HC in the first hour post meal (p =.005), but continued to decline between 60 and 120 minutes post meal, whereas HC plateaued (p =.005). Fasting and PYY trajectory did not differ by group. Findings did not change after adjusting for BMI percentile (M(SD)

Indexed as

Avoidant Restrictive Food Intake DisorderEatingFastingGhrelinPeptide YYPostprandial PeriodAdolescentAppetiteBody Mass IndexChildFemaleHumansMaleMealsYoung AdultGhrelinPeptide YYAppetite-regulating hormonesARFIDAvoidant/restrictive food intake disorderfeeding and eating disordersGhrelinLatent growth curve modelingPeptide YY

Identifiers

PMID38896990
PMCPMC11341102

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.