Evidence map›Paper›PMID 38897566›Full record

ArticleThe Journal of biological chemistry2024

Decline in corepressor CNOT1 in the pregnant myometrium near term impairs progesterone receptor function and increases contractile gene expression.

Youn-Tae Kwak, Alina P Montalbano, Andrew M Kelleher, Mariano Colon-Caraballo, W Lee Kraus, Mala Mahendroo, Carole R Mendelson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Youn-Tae KwakDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Alina P MontalbanoDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Andrew M KelleherDepartment of Obstetrics & Gynecology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA; Laboratory of Signaling and Gene Regulation, The University of Texas Southwestern Medical Center, Dallas, Texas, USA; Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, Missouri, USA.
Mariano Colon-CaraballoDepartment of Obstetrics & Gynecology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA; Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
W Lee KrausLaboratory of Signaling and Gene Regulation, The University of Texas Southwestern Medical Center, Dallas, Texas, USA; Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Mala MahendrooDepartment of Obstetrics & Gynecology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA; Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address: mala.mahendroo@utsouthwestern.edu.
Carole R MendelsonDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Obstetrics & Gynecology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA; Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, Texas, USA; North Texas March of Dimes Birth Defects Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Funding

Dose-Dependent Effects of Hormone on the Activity of Estrogen Receptor Enhancers and Target GenesR01DK058110 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WILLIAM Lee KRAUS · 2000 to 2026
$10.4M
Molecular and Genomic Mechanisms in the Biology of Pregnancy and ParturitionP01HD087150 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI KRAUS, WILLIAM LEE · 2017 to 2021
$6.7M
NICHD NIH HHS P01 HD087150NIDDK NIH HHS R01 DK058110
6 · The paper itself

Abstract

Progesterone (P

Indexed as

MyometriumPromoter Regions, GeneticReceptors, ProgesteroneAnimalsConnexin 43FemaleGene Expression RegulationHumansMiceNF-kappa BPregnancyProgesteroneTranscription FactorsUterine ContractionCnot1 protein, mouseConnexin 43NF-kappa BProgesteroneReceptors, ProgesteroneTranscription Factorsgene regulationinflammationmyometrial quiescencemyometriumNF-κBpregnancyprogesteronetranscription corepressoruterine contraction

Identifiers

PMID38897566
PMCPMC11301068

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.