Evidence map›Paper›PMID 38898137›Full record

ArticleScientific reports2024

LRG1 and SDR16C5 protein expressions differ according to HPV status in oropharyngeal squamous cell carcinoma.

Reija Randén-Brady, Timo Carpén, Laura C Hautala, Tuomas Tolvanen, Caj Haglund, Sakari Joenväärä, Petri Mattila, Antti Mäkitie, Sanna Lehtonen, Jaana Hagström and 1 more

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Reija Randén-BradyDepartment of Pathology, University of Helsinki, 00014, Helsinki, Finland. reija.randen-brady@hus.fi.ORCID https://orcid.org/0000-0002-6393-2281
Timo CarpénDepartment of Pathology, University of Helsinki, 00014, Helsinki, Finland.ORCID https://orcid.org/0000-0003-0117-8559
Laura C HautalaResearch Program for Clinical and Molecular Metabolism, University of Helsinki, 00014, Helsinki, Finland.ORCID https://orcid.org/0000-0002-5501-2792
Tuomas TolvanenDepartment of Pathology, University of Helsinki, 00014, Helsinki, Finland.ORCID https://orcid.org/0000-0002-3581-208X
Caj HaglundUniversity of Helsinki, and Helsinki University Hospital, 00029, Helsinki, Finland.ORCID https://orcid.org/0000-0003-0456-4965
Sakari JoenvääräTransplantation Laboratory, Haartman Institute, University of Helsinki and Helsinki University Hospital, 00029, Helsinki, Finland.ORCID https://orcid.org/0000-0002-6378-8726
Petri MattilaDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki, and Helsinki University Hospital, 00029, Helsinki, Finland.ORCID https://orcid.org/0000-0003-1911-1811
Antti MäkitieDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki, and Helsinki University Hospital, 00029, Helsinki, Finland.ORCID https://orcid.org/0000-0002-0451-2404
Sanna LehtonenDepartment of Pathology, University of Helsinki, 00014, Helsinki, Finland.ORCID https://orcid.org/0000-0003-4189-2415
Jaana Hagström *Department of Pathology, University of Helsinki, 00014, Helsinki, Finland.ORCID https://orcid.org/0000-0001-6079-7881
Suvi Silén *Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki, and Helsinki University Hospital, 00029, Helsinki, Finland.ORCID https://orcid.org/0000-0003-1240-0661

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) is primarily due to human papillomavirus, and understanding the tumor biology caused by the virus is crucial. Our goal was to investigate the proteins present in the serum of patients with OPSCC, which were not previously studied in OPSCC tissue. We examined the difference in expression of these proteins between HPV-positive and -negative tumors and their correlation with clinicopathological parameters and patient survival. The study included 157 formalin-fixed, paraffin-embedded tissue samples and clinicopathological data. Based on the protein levels in the sera of OPSCC patients, we selected 12 proteins and studied their expression in HPV-negative and HPV-positive OPSCC cell lines. LRG1, SDR16C5, PIP4K2C and MVD proteins were selected for immunohistochemical analysis in HPV-positive and -negative OPSCC tissue samples. These protein´s expression levels were compared with clinicopathological parameters and patient survival to investigate their clinical relevance. LRG1 expression was strong in HPV-negative whereas SDR16C5 expression was strong in HPV-positive tumors. Correlation was observed between LRG1, SDR16C5, and PIP4K2C expression and patient survival. High expression of PIP4K2C was found to be an independent prognostic factor for overall survival and expression correlated with HPV-positive tumor status. The data suggest the possible role of LRG1, SDR16C5 and PIP4K2C in OPSCC biology.

Indexed as

Oropharyngeal NeoplasmsPapillomavirus InfectionsAdultAgedAldehyde OxidoreductasesBiomarkers, TumorCarcinoma, Squamous CellCell Line, TumorFemaleGlycoproteinsHumansMaleMiddle AgedPapillomaviridaePrognosisSquamous Cell Carcinoma of Head and NeckAldehyde OxidoreductasesBiomarkers, TumorGlycoproteinsLRG1 protein, humanSDR16C5 protein, human

Identifiers

PMID38898137
PMCPMC11187215

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.