Evidence map›Paper›PMID 38898279›Full record

ArticleNature2024

dsRNA formation leads to preferential nuclear export and gene expression.

Ivo Coban, Jan-Philipp Lamping, Anna Greta Hirsch, Sarah Wasilewski, Orr Shomroni, Oliver Giesbrecht, Gabriela Salinas, Heike Krebber

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  17. Article
  18. The RNA Revolution in the Central Molecular Biology Dogma Evolution.International journal of molecular sciences · 2024
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ivo CobanAbteilung für Molekulare Genetik, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August Universität Göttingen, Göttingen, Germany.
Jan-Philipp LampingAbteilung für Molekulare Genetik, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August Universität Göttingen, Göttingen, Germany.
Anna Greta HirschAbteilung für Molekulare Genetik, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August Universität Göttingen, Göttingen, Germany.
Sarah WasilewskiAbteilung für Molekulare Genetik, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August Universität Göttingen, Göttingen, Germany.
Orr ShomroniNGS-Integrative Genomics Core Unit, Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.
Oliver GiesbrechtAbteilung für Molekulare Genetik, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August Universität Göttingen, Göttingen, Germany.ORCID 0000-0002-1222-5878
Gabriela SalinasNGS-Integrative Genomics Core Unit, Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.
Heike KrebberAbteilung für Molekulare Genetik, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August Universität Göttingen, Göttingen, Germany. heike.krebber@biologie.uni-goettingen.de.ORCID 0000-0001-6531-0710

Funding

University of Göttingen and the Deutsche Forschungsgemeinschaft
6 · The paper itself

Abstract

When mRNAs have been transcribed and processed in the nucleus, they are exported to the cytoplasm for translation. This export is mediated by the export receptor heterodimer Mex67-Mtr2 in the yeast Saccharomyces cerevisiae (TAP-p15 in humans)

Indexed as

Active Transport, Cell NucleusCell NucleusGene Expression Regulation, FungalRNA, AntisenseRNA, Double-StrandedRNA, MessengerRNA TransportSaccharomyces cerevisiaeCytoplasmDEAD-box RNA HelicasesMembrane Transport ProteinsNuclear ProteinsNucleocytoplasmic Transport ProteinsRNA-Binding ProteinsSaccharomyces cerevisiae ProteinsDbp2 protein, S cerevisiaeDEAD-box RNA HelicasesMembrane Transport ProteinsMEX67 protein, S cerevisiaeMtr2 protein, S cerevisiaeNuclear ProteinsNucleocytoplasmic Transport ProteinsRNA, AntisenseRNA-Binding ProteinsRNA, Double-StrandedRNA, MessengerSaccharomyces cerevisiae Proteins

Identifiers

PMID38898279
PMCPMC11236707

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.