ArticleThe New England journal of medicine2024
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Article in The New England journal of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
–field-weighted citation impact
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Who cites it
33 citing papers in PubMed.
- Review
- APOE3 Christchurch is associated with sphingolipids recycling and glial lipid remodeling in autosomal dominant Alzheimer's disease.Research square · 2026Article
- Protective mutations associated with APOE in Alzheimer's disease.Molecular psychiatry · 2026Review
- Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study.The Lancet. Neurology · 2026Article
- Alzheimer disease protection from the periphery.Nature reviews. Neurology · 2026Article
- Circulating lipids uncover early membrane disruption as a primary event preceding Alzheimer's disease onset.Research square · 2026Article
- Decoding unchanged transcriptome of Alzheimer's disease reveals an NCAM1 mRNA switch as a potential biomarker.iScience · 2026Article
- A critical appraisal of the link between apolipoprotein E and Tau.Current opinion in neurology · 2026Review
- Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice.Translational psychiatry · 2026Article
- Toward personalized medicine in AD/ADRD through genetic-exposome dementia risk assessments.NPJ dementia · 2026Review
- Mechanistic role of APOE lipidation in Alzheimer's disease pathogenesis.Theranostics · 2026Review
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- The Janus face of CaMKII: from memory consolidation to neurotoxic switch in Alzheimer's disease.Archives of toxicology · 2025Review
- Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries.Nature communications · 2025Article
- Recent Advances and Future Directions in Alzheimer's Disease Genetic Research.International journal of molecular sciences · 2025Review
- A manifesto for Alzheimer's disease drug discovery in the era of disease-modifying therapies.Molecular neurodegeneration · 2025Review
- APOE2 reduces risk of Alzheimer's disease by protection of lysosomes from lipid overloading.Acta pharmaceutica Sinica. B · 2025Article
- A novel approach to resilience and its links with education and Alzheimer's disease genetics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Protective genetic variants against Alzheimer's disease.The Lancet. Neurology · 2025Review
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Authors and funding
30 authors.
Yakeel T QuirozFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).ORCID 0000-0001-9714-8244
David AguillonFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Daniel C Aguirre-AcevedoFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Daniel VasquezFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).ORCID 0000-0002-2586-162X
Yesica ZuluagaFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Ana Y BaenaFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Lucia MadrigalFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Liliana HincapiéFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Justin S SanchezFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Stephanie LangellaFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Rafael Posada-DuqueFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Jessica L LittauFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Nelson D Villalba-MorenoFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Clara Vila-CastelarFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Liliana Ramirez GomezFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Gloria GarciaFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Elizabeth KaplanFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Sofia Rassi VargasFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
J Alejandro OssaFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Pablo Valderrama-CarmonaFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Paula Perez-CorredorFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Susanne KrasemannFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).ORCID 0000-0001-8795-818X
Markus GlatzelFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).ORCID 0000-0002-7720-8817
Kenneth S KosikFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Keith JohnsonFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Reisa A SperlingFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Eric M ReimanFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Diego Sepulveda-FallaFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).ORCID 0000-0003-0176-2042
Francisco LoperaFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Joseph F Arboleda-VelasquezFrom Massachusetts General Hospital (Y.T.Q., J.S.S., S.L., C.V.-C., L.R.G., E.K., K.J., R.A.S.), the Departments of Neurology (Y.T.Q., J.S.S., L.R.G., K.J., R.A.S.), Psychiatry (Y.T.Q., S.L., C.V.-C., E.K.), and Ophthalmology (P.P.-C., J.F.A.-V.), Harvard Medical School, Brigham and Women's Hospital (K.J., R.A.S.), and Schepens Eye Research Institute, Mass Eye and Ear (P.P.-C., J.F.A.-V.) - all in Boston; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia (Y.T.Q., D.A., D.C.A-A., D.V., Y.Z., A.Y.B., L.M., L.H., R.P.-D., G.G., S.R.V., J.A.O., P.V.-C., F.L.); the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.L.L., N.D.V.-M., S.K., M.G., D.S-F.); the Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara (K.S.K.); and the Banner Alzheimer's Institute, Phoenix, the University of Arizona, Tucson, and Arizona State University, Tempe - all in Arizona (E.M.R.).
Funding
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI HEATHER Allyson BIMONTE-NELSON · 2021 to 2026
$24.9MResilience to Cognitive Decline and Resistance to Alzheimer's Disease and Related Neurodegenerative Diseases in Individuals from Colombia with Autosomal Dominant DementiasRM1NS132996 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI AGUILLON, DAVID FERNANDO, ARBOLEDA-VELASQUEZ, JOSEPH · 2023 to 2023
$3.8MRelationship between tau pathology and cognitive impairment in autosomal dominant Alzheimer's diseaseR01AG054671 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI QUIROZ, YAKEEL T. · 2017 to 2021
$3.8MCharting vascular contributions to white matter disease in familial Alzheimer's disease and CADASILRF1NS110048 · NINDS · SCHEPENS EYE RESEARCH INSTITUTE · PI ARBOLEDA-VELASQUEZ, JOSEPH, SEPULVEDA-FALLA, DIEGO · 2018 to 2019
$3.6MNerve growth factor (NGF) metabolic dysfunction as a marker of cognitive decline in autosomal dominant Alzheimer's diseaseRF1AG077627 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI AGUILLON, DAVID FERNANDO, CUELLO, A CLAUDIO · 2022 to 2022
$2.0MThe complex interaction between Alzheimer drivers and agingR01AG062479 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI KOSIK, KENNETH STEPHEN · 2024 to 2024
$620kExamining the impact of sex and hormones on the progression of autosomal dominant Alzheimer's diseaseK99AG073452 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI VILA CASTELAR, CLARA · 2022 to 2023
$268kNIA NIH HHS K99 AG073452NIA NIH HHS P30 AG072980NIA NIH HHS P30AG072980NIA NIH HHS R01 AG054671NIA NIH HHS R01 AG062479NIA NIH HHS RF1 AG077627NINDS and NIA RF1NS110048NINDS NIH HHS RF1 NS110048NINDS NIH HHS RM1 NS132996NINDS NIH HHS RM1NS132996
Abstract
backgroundVariants in
methodsWe analyzed data from 27 participants with one copy of the
resultsAmong carriers of
conclusionsClinical data supported a delayed onset of cognitive impairment in persons who were heterozygous for the
Indexed as
Alzheimer DiseaseApolipoprotein E3Presenilin-1AdultAgedAge of OnsetBrainColombiaFamilyFemaleGenes, DominantHeterozygoteHumansMaleMiddle AgedPositron-Emission TomographyApolipoprotein E3Presenilin-1PSEN1 protein, human
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.