Evidence map›Paper›PMID 38901535›Full record

ArticleGene2024

Contribution of circulating Mfge8 to human T2DM and cardiovascular disease.

Madhusmita Rout, Megan W Malone-Perez, Gilseung Park, Megan Lerner, J Kimble Frazer, Blair Apple, April Vaughn, Marvin Payton, Stavros Stavrakis, Evgeny Sidorov and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Madhusmita RoutDepartment of Pediatrics, Section of Genetics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Megan W Malone-PerezDepartment of Pediatrics, Section of Hematology and Oncology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Gilseung ParkDepartment of Pediatrics, Section of Hematology and Oncology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Megan LernerDepartment of Surgery, Oklahoma University of Health Sciences Center, Oklahoma City, OK, USA.
J Kimble FrazerDepartment of Pediatrics, Section of Hematology and Oncology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Blair AppleDepartment of Neurology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
April VaughnDepartment of Neurology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Marvin PaytonDepartment of Surgery, Oklahoma University of Health Sciences Center, Oklahoma City, OK, USA.
Stavros StavrakisDepartment of Cardiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Evgeny SidorovDepartment of Neurology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
KarMing A FungDepartment of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Dharambir K SangheraDepartment of Pediatrics, Section of Genetics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address: Dharambir-sanghera@ouhsc.edu.

Funding

Genome, Metabolome, Ancestry and Diabetes Health DisparityR01DK118427 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DUGGIRALA, RAVINDRANATH, GORING, HARALD HEINZ HERBERT · 2019 to 2023
$2.5M
Genome-wide Association Scan to Identify Risk Genes for Type 2 Diabetes in AsianR01DK082766 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI SANGHERA, DHARAMBIR K. · 2009 to 2011
$2.3M
NIDDK NIH HHS R01 DK082766NIDDK NIH HHS R01 DK118427
6 · The paper itself

Abstract

MFGE8 is a major exosome (EV) protein known to mediate inflammation and atherosclerosis in type 2 diabetes mellitus (T2DM) in animal studies. The pathophysiological role of this protein in obesity, T2DM, and cardiovascular disease is less investigated in humans. Earlier we reported a rare Asian Indian population-specific missense variant (rs371227978; Arg148His) in the MFGE8 gene associated with increased circulating Mfge8 and T2DM. We have further investigated the role of Mfge8 with T2DM risk in additional Asian Indians (n = 4897) and Europeans and other multiethnic cohorts from UK Biobank (UKBB) (n = 455,808) and the US (n = 1150). We also evaluated the exposure of Mfge8-enriched human EVs in zebrafish (ZF) for their impact on cardiometabolic organ system. Most individual carriers of Arg148His variant not only had high circulating Mfge8 but also revealed a positive significant correlation with glucose (r = 0.42; p = 4.9 × 10

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2ZebrafishAdultAgedAnimalsAsian PeopleBlood GlucoseExosomesFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedMutation, MissensePolymorphism, Single NucleotideBlood GlucoseCardiometabolic diseaseCirculating Mfge8ExosomesRare variantsZebrafish

Identifiers

PMID38901535
PMCPMC11348863

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.