ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2024
Quality over quantity: powering neuroimaging samples in psychiatry.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Sustained effects of repeated levodopa (L-DOPA) administration on reward circuitry, effort-based motivation, and anhedonia in depressed patients with higher inflammation.Brain, behavior, and immunity · 2025Trial
- The geometry of disorder: fractal analysis in psychiatric neuroimaging.European radiology · 2026Article
- The Adolescent Brain Cognitive Development (ABCD) Study: Ten years of statistical and methodological contributions.Developmental cognitive neuroscience · 2026Article
- HARMONY: A large-scale harmonized neuroimaging dataset for research on anxious misery disorders.bioRxiv : the preprint server for biology · 2026Article
- Altered frontal and occipital cortical microstructure in obsessive-compulsive disorder - a multisite mega-analysis.Molecular psychiatry · 2026Article
- External validation improves generalizability, replicability and reproducibility in predictive models for neuroimaging.Nature methods · 2026Review
- Cortical Structure in Relation to Empathy and Psychopathy in 800 Incarcerated Men.Biological psychiatry global open science · 2026Article
- Increasing visibility of the neurobiology of eating disorders in youth - a commentary on Hagan et al. (2025).Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Independent brain cortical signatures of risk for adolescent cannabis use and consequences of such use are moderated by sex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders.Molecular psychiatry · 2025Article
- Cortical structure in relation to empathy and psychopathy in 800 incarcerated men.bioRxiv : the preprint server for biology · 2025Article
- Improving predictability, reliability, and generalizability of brain-wide associations for cognitive abilities via multimodal stacking.PNAS nexus · 2025Article
- Reduced recruitment of inhibitory control regions in very young children with ADHD during a modified Kiddie Continuous Performance Task: A fMRI study.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Optimizing working memory assessment: development of shortened versions of complex spans, updating, and binding tasks.Psychological research · 2025Article
- Comparing and scaling fMRI features for brain-behavior prediction.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Precision neurodiversity: personalized brain network architecture as a window into cognitive variability.Frontiers in human neuroscience · 2025Review
- An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024Review
- Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders.medRxiv : the preprint server for health sciences · 2024Article
- Illness-related variables and abnormalities of resting-state brain activity in schizophrenia.Frontiers in psychiatry · 2024Article
- Meta-analysis of structural and functional brain abnormalities in early-onset schizophrenia.Frontiers in psychiatry · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Neuroimaging has been widely adopted in psychiatric research, with hopes that these non-invasive methods will provide important clues to the underpinnings and prediction of various mental health symptoms and outcomes. However, the translational impact of neuroimaging has not yet reached its promise, despite the plethora of computational methods, tools, and datasets at our disposal. Some have lamented that too many psychiatric neuroimaging studies have been underpowered with respect to sample size. In this review, we encourage this discourse to shift from a focus on sheer increases in sample size to more thoughtful choices surrounding experimental study designs. We propose considerations at multiple decision points throughout the study design, data modeling and analysis process that may help researchers working in psychiatric neuroimaging boost power for their research questions of interest without necessarily increasing sample size. We also provide suggestions for leveraging multiple datasets to inform each other and strengthen our confidence in the generalization of findings to both population-level and clinical samples. Through a greater emphasis on improving the quality of brain-based and clinical measures rather than merely quantity, meaningful and potentially translational clinical associations with neuroimaging measures can be achieved with more modest sample sizes in psychiatry.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.