Evidence map›Paper›PMID 38902502›Full record

ArticleActa pharmacologica Sinica2024

Structural basis of tolvaptan binding to the vasopressin V

Hong-Li Liu, Hai-Yang Zhong, Yi-Xiao Zhang, Hua-Rui Xue, Zheng-Shuo Zhang, Ke-Quan Fu, Xu-Dong Cao, Xiao-Chun Xiong, Dong Guo

Abstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong-Li Liu *Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.
Hai-Yang Zhong *Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.
Yi-Xiao Zhang *Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.
Hua-Rui XueJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.
Zheng-Shuo ZhangJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.
Ke-Quan FuJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.
Xu-Dong CaoJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.
Xiao-Chun XiongJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China. xiaochun.xiong@xzhmu.edu.cn.
Dong GuoJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China. guo@xzhmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vasopressin V

Indexed as

Antidiuretic Hormone Receptor AntagonistsMolecular Dynamics SimulationReceptors, VasopressinTolvaptanBenzazepinesBinding SitesHEK293 CellsHumansMutagenesis, Site-DirectedProtein BindingProtein ConformationAntidiuretic Hormone Receptor AntagonistsAVPR2 protein, humanBenzazepinesReceptors, VasopressinTolvaptanbinding pathwaygaussian accelerated molecular dynamics (GaMD) simulationstolvaptanvasopressin V2 receptor (V2R)

Identifiers

PMID38902502
PMCPMC11489814

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.