Evidence map›Paper›PMID 38905101›Full record

ArticleCell reports2024

Retrograde adenosine/A

Kaoutsar Nasrallah, Coralie Berthoux, Yuki Hashimotodani, Andrés E Chávez, Michelle C Gulfo, Rafael Luján, Pablo E Castillo

Abstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Adenosine in the Brain: Recent Progress on Detection, Function, and Translation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  5. Review
  6. Adenosine ANeuropharmacology · 2025
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Kaoutsar NasrallahDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Coralie BerthouxDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Yuki HashimotodaniDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Andrés E ChávezDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Michelle C GulfoDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Rafael LujánInstituto de Biomedicina de la UCLM (IB-UCLM), Facultad de Medicina, Universidad Castilla-La Mancha, 02008 Albacete, Spain.
Pablo E CastilloDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Psychiatry & Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: pablo.castillo@einsteinmed.edu.

Funding

SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Julie Secombe · 2021 to 2026
$7.0M
Presynaptic forms of long-term plasticity in the CNSR01MH125772 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI PABLO E CASTILLO · 2020 to 2026
$3.6M
Synaptic Mechanisms for Contextual Memory FormationR01MH116673 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI CASTILLO, PABLO E, LIN, YINGXI · 2019 to 2023
$3.4M
Activity-Dependent Plasticity in an Associative Hippocampal Circuit: Mechanisms, Synaptic Learning Rules and Involvement in DiseaseR01NS113600 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI CASTILLO, PABLO E · 2019 to 2023
$2.7M
Zeiss Confocal Microscope with Airyscan for Einstein Neural Cell Engineering and Imaging CoreS10OD025295 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI DOBRENIS, KOSTANTIN · 2019 to 2019
$523k
Assessing dopaminergic modulation of an associative circuit within the dentate gyrusF31MH122134 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI GULFO, MICHELLE C · 2019 to 2021
$137k
Role of TRPV1 channels in synaptic transmission and plasticity in the hippocampusF32NS071821 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI CHAVEZ, ANDRES · 2010 to 2011
$104k
NICHD NIH HHS P50 HD105352NIH HHS S10 OD025295NIMH NIH HHS F31 MH122134NIMH NIH HHS R01 MH116673NIMH NIH HHS R01 MH125772NINDS NIH HHS F32 NS071821NINDS NIH HHS R01 NS113600
6 · The paper itself

Abstract

Retrograde signaling at the synapse is a fundamental way by which neurons communicate and neuronal circuit function is fine-tuned upon activity. While long-term changes in neurotransmitter release commonly rely on retrograde signaling, the mechanisms remain poorly understood. Here, we identified adenosine/A

Indexed as

AdenosineLong-Term PotentiationReceptor, Adenosine A2ASeizuresSignal TransductionSynaptic TransmissionAnimalsBrain-Derived Neurotrophic FactorDentate GyrusHippocampusMaleMiceMice, Inbred C57BLReceptor, trkBAdenosineBrain-Derived Neurotrophic FactorReceptor, Adenosine A2AReceptor, trkBBDNFCP: Neurosciencedentate gyrusepilepsyhippocampusLTPmossy cellPKApresynapticretrograde signalingTrkB

Identifiers

PMID38905101
PMCPMC11286346

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.