Evidence map›Paper›PMID 38906962›Full record

ArticleLeukemia2024

Asciminib antagonizes transplantable BCR::ABL1-positive lymphoid blast crisis in vivo by targeting malignant stem cells.

Nicolas Chatain, Julian Baumeister, Marcelo A Szymanski de Toledo, Dickson W L Wong, Siddharth Gupta, Kristina Pannen, Bärbel Junge, Tim H Brümmendorf, Peter Boor, Steffen Koschmieder

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. A new chapter in CML treatment: the promise of asciminib.Annals of medicine and surgery (2012) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicolas ChatainDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany. nchatain@ukaachen.de.ORCID 0000-0003-4485-3120
Julian BaumeisterDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Marcelo A Szymanski de ToledoDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Dickson W L WongCenter for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.
Siddharth GuptaDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Kristina PannenDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Bärbel JungeDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Tim H BrümmendorfDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.ORCID 0000-0002-9677-3723
Peter BoorCenter for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.ORCID 0000-0001-9921-4284
Steffen KoschmiederDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany. skoschmieder@ukaachen.de.ORCID 0000-0002-1011-8171

Funding

Novartis | Novartis Pharma (Novartis Deutschland GmbH) HABL001
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Blast CrisisFusion Proteins, bcr-ablNeoplastic Stem CellsAnimalsHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMiceNiacinamideProtein Kinase InhibitorsProto-Oncogene Proteins c-ablPyrazolesasciminibFusion Proteins, bcr-ablNiacinamideProtein Kinase InhibitorsProto-Oncogene Proteins c-ablPyrazoles

Identifiers

PMID38906962
PMCPMC11286509

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.