Evidence map›Paper›PMID 38909111›Full record

SynthesisInternational ophthalmology2024

Multiple neoplasms in patients with uveal melanoma: a systematic review.

Elia de Esteban Maciñeira, Pablo Fernández Fernández, Iria Conde González, Manuel Francisco Bande Rodríguez, María José Blanco Teijeiro

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elia de Esteban MaciñeiraDepartment of Ophthalmology, University Hospital of Santiago de Compostela, Ramón Baltar S/N, 15706, Santiago de Compostela, Spain. elia.de.esteban.macineira@sergas.es.ORCID http://orcid.org/0000-0002-2247-1343
Pablo Fernández FernándezDepartment of Surgery and Medical-Surgical Specialties, University of Santiago de Compostela, Santiago de Compostela, Spain.
Iria Conde GonzálezDepartment of Ophthalmology, University Hospital of Orense, Ourense, Spain.
Manuel Francisco Bande RodríguezDepartment of Ophthalmology, University Hospital of Santiago de Compostela, Ramón Baltar S/N, 15706, Santiago de Compostela, Spain.
María José Blanco TeijeiroDepartment of Ophthalmology, University Hospital of Santiago de Compostela, Ramón Baltar S/N, 15706, Santiago de Compostela, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUveal melanoma is the most prevalent intraocular malignancy in adults, derived from uveal tract melanocytes. This study focuses on the frequency and risk of second primary malignancies in UM patients.

methodsA PubMed search (1980-2023) identified studies on SPM incidence in UM patients. From 191 references, 14 studies were chosen, focusing on UM, SPMs, and analysing data on demographics and types of neoplasms.

resultsAmong 31,235 UM patients in 14 studies, 4695 had 4730 SPMs (15.03% prevalence). Prostate (15%), breast (12%), and colorectal (9%) cancers were most common. Digestive system malignancies were highest (19%), with colorectal cancer leading (51%). Breast and prostate cancers were prevalent in respective systems. Lung, bladder, and non-Hodgkin's lymphoma were also notable. The study observed an increasing trend in the frequency of SPMs over time, reflecting broader trends in cancer survivorship and the growing prevalence of multiple malignancies.

conclusionThe study highlights a significant presence of SPMs in UM patients, with an increasing trend in frequency over time, emphasizing prostate and breast cancers. This underscores the need for focused surveillance and tailored follow-up for UM survivors, considering their higher risk of additional malignancies. Future research should further investigate SPM aetiology in UM patients.

Indexed as

MelanomaUveal NeoplasmsHumansIncidenceNeoplasms, Multiple PrimaryNeoplasms, Second PrimaryPrevalenceRisk FactorsUveal MelanomaMultiple neoplasmsNew primary cancerOcular melanomaSecond primary malignancySecond primary neoplasmUveal melanoma

Identifiers

PMID38909111

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.