Evidence map›Paper›PMID 38909214›Full record

ArticleBMC women's health2024

The association between endometrial polyps and insulin resistance from the expression of PI3K and AKT proteins perspective.

Xuelin Li, Feifan Wang, Mengzhu Chen, Li Ling, Fengfeng Zhao, Danhong Peng

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Article in BMC women's health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Comprehensive Analysis of Risk Factors for Recurrence in Women of Reproductive Age Undergoing Hysteroscopic Polypectomy.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xuelin LiDepartment of Obstetrics and Gynecology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, People's Republic of China.
Feifan WangDepartment of Obstetrics and Gynecology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, People's Republic of China.
Mengzhu ChenDepartment of Obstetrics and Gynecology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, People's Republic of China.
Li LingCenter for Reproductive Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, People's Republic of China.
Fengfeng ZhaoCenter of Clinical Laboratory Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, People's Republic of China. 230218489@seu.edu.cn.
Danhong PengDepartment of Obstetrics and Gynecology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInsulin resistance (IR) induces hyperinsulinemia, which activates downstream signaling pathways such as the phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) pathway, ultimately leading to abnormal proliferation and apoptosis of endometrial cells. This is thought to be a key pathogenic mechanism underlying the development of endometrial polyps (EP). This study aims to investigate the relationship between IR and the development of EP, the expression levels of downstream signaling molecules, including PI3K and AKT, and related laboratory parameters were examined.

methodsA total of 100 patients who visited the gynecology outpatient clinic of Zhongda Hospital affiliated with Southeast University from May 2021 to March 2023 and were diagnosed with abnormal endometrial echoes by vaginal ultrasound and underwent hysteroscopic diagnostic curettage were enrolled in this study. General data and relevant hematological indicators were compared, and intraoperative specimens were obtained for pathological examination. Possible factors influencing the development of endometrial polyps were analyzed using Pearson correlation analysis and logistic regression analysis.

resultsIn terms of body mass index, waist circumference, fasting insulin, insulin resistance index, serum total testosterone, and free testosterone index, women of childbearing age in the endometrial polyp group had higher values than those in the non-polyp group, while sex hormone-binding globulin in the endometrial polyp group was lower than that in the non-polyp group, and the differences were statistically significant (P < 0.05). The expression scores and mRNA expression levels of PI3K and AKT proteins were higher in the EP group than in the non-EP group (p < 0.05). Pearson correlation analysis showed a positive correlation between HOMA-IR and the expression scores of PI3K and AKT proteins (p < 0.01).

conclusionsInsulin resistance and abnormal activation of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway may be potential pathogenic mechanisms for the development of endometrial polyps.

Indexed as

Insulin ResistancePhosphatidylinositol 3-KinasesPolypsProto-Oncogene Proteins c-aktAdultBody Mass IndexEndometriumFemaleHumansInsulinMiddle AgedSex Hormone-Binding GlobulinSignal TransductionTestosteroneUterine DiseasesInsulinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSex Hormone-Binding GlobulinTestosteroneEndometrial polypsInsulin resistancePhosphatidylinositol 3-kinaseProtein kinase B

Identifiers

PMID38909214
PMCPMC11193179

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.