Evidence map›Paper›PMID 38910467›Full record

ReviewCurrent drug targets2024

Multi-target Compounds against Trypanosomatid Parasites and

Midiane Correia Gomes, Emanuelly Karla Araújo Padilha, Gustavo Rafael Angelo Diniz, Edilma Correia Gomes, Paulo Fernando da Silva Santos-Júnior, Peng Zhan, Edeildo Ferreira da Siva-Júnior

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current drug targets, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Midiane Correia GomesResearch Group in Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Campus AC. Simões, CEP 57072-970, Maceió-AL, Brazil.ORCID 0009-0005-3236-6167
Emanuelly Karla Araújo PadilhaResearch Group in Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Campus AC. Simões, CEP 57072-970, Maceió-AL, Brazil.ORCID 0009-0002-3932-9068
Gustavo Rafael Angelo DinizResearch Group in Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Campus AC. Simões, CEP 57072-970, Maceió-AL, Brazil.
Edilma Correia GomesResearch Group in Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Campus AC. Simões, CEP 57072-970, Maceió-AL, Brazil.
Paulo Fernando da Silva Santos-JúniorResearch Group in Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Campus AC. Simões, CEP 57072-970, Maceió-AL, Brazil.
Peng ZhanDepartment of Medicinal - Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P.R. China.
Edeildo Ferreira da Siva-JúniorResearch Group in Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Campus AC. Simões, CEP 57072-970, Maceió-AL, Brazil.ORCID 0000-0002-1527-4501

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior code 001
6 · The paper itself

Abstract

Multi-target drug treatment has become popular as a substitute for traditional monotherapy. Monotherapy can lead to resistance and side effects. Multi-target drug discovery is gaining importance as data on bioactivity becomes more abundant. The design of multi-target drugs is expected to be an important development in the pharmaceutical industry in the near future. This review presents multi-target compounds against trypanosomatid parasites (

Indexed as

Antitubercular AgentsMolecular Docking SimulationMycobacterium tuberculosisAnimalsDrug DesignDrug DiscoveryHumansLeishmaniaTrypanocidal AgentsTrypanosoma cruziTuberculosisAntitubercular AgentsTrypanocidal Agentsleishmaniasismonotherapy.Multi-target compoundsneglected tropical diseasestrypanosomatuberculosis

Identifiers

PMID38910467

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.