Evidence map›Paper›PMID 38914676›Full record

ArticleActa pharmacologica Sinica2024

Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrL

Jian-Chi Ma, Xiao-Hang Che, Xiao-Na Zhu, Ao-Xin Ren, Yue Hu, Cheng-Li Yang, Zhong-Tian Xu, Yu-Ting Li, Chun-Fu Wu, Jing-Yu Yang

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In one paragraph

Article in Acta pharmacologica Sinica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jian-Chi MaDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Xiao-Hang CheDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Xiao-Na ZhuSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Ao-Xin RenDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Yue HuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Cheng-Li YangDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Zhong-Tian XuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Yu-Ting LiDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Chun-Fu WuDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China. wucf@syphu.edu.cn.
Jing-Yu YangDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China. yangjingyu2006@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methamphetamine (METH), an abused psychostimulant, impairs cognition through prolonged or even single-dose exposure, but animal experiments have shown contradictory effects on memory deficits. In this study we investigated the effects and underlying mechanisms of single-dose METH administration on the retrieval of object recognition memory (ORM) in mice. We showed that single-dose METH administration (2 mg/kg, i.p.) significantly impaired ORM retrieval in mice. Fiber photometry recording in METH-treated mice revealed that the activity of prelimbic cortex glutamatergic neurons (PrL

Indexed as

DopamineMethamphetamineMice, Inbred C57BLAnimalsCentral Nervous System StimulantsDopamine D2 Receptor AntagonistsGlutamic AcidMaleMiceNeuronsPrefrontal CortexReceptors, Dopamine D2Recognition, PsychologySulpirideCentral Nervous System StimulantsDopamineDopamine D2 Receptor AntagonistsGlutamic AcidMethamphetamineReceptors, Dopamine D2Sulpiridecognitive deficitsD2 receptorsmemory retrieval impairmentmethamphetamineobject recognition memoryprelimbic cortex

Identifiers

PMID38914676
PMCPMC11489666

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.