Evidence map›Paper›PMID 38914839›Full record

ArticleCell biochemistry and biophysics2024

Unraveling the Drug Response Heterogeneity with Single-Cell Vibrational Phenomics.

Yue Wang, Yadi Wang, Junhong Lü, Xueling Li

Abstract read
PubMed Publisher
In one paragraph

Article in Cell biochemistry and biophysics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yue WangCollage of Public Health, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Yadi WangCollege of Pharmacy, Binzhou Medical University, Yantai, 264003, China. Wangydcas@163.com.
Junhong LüCollege of Pharmacy, Binzhou Medical University, Yantai, 264003, China. lvjunhong@jnl.ac.cn.
Xueling LiCollage of Public Health, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China. lixl@sumhs.edu.cn.

Funding

National Natural Science Foundation of China U2230110Shandong Provincial Natural Science Foundation ZR2021QC029
6 · The paper itself

Abstract

Drug responses heterogeneity is often highlighted to justify the need for precision medicine. However, due to the highly complex nature of cell phenotypes in many diseases, one of key challenges is how to obtain the high content features in a cellular population. Here we present a single-cell vibrational phenomics approach, integrating synchrotron infrared microspectroscopy and multivariate calculation, for quantitatively evaluating the cellular responses to drug perturbation with single cell resolution. In a human hepatocellular carcinoma HepG

Indexed as

PaclitaxelSingle-Cell AnalysisHep G2 CellsHumansPhenomicsSapogeninsSpectroscopy, Fourier Transform InfraredVibrationPaclitaxelSapogeninsCellular heterogeneityDrug responseInfrared microspectroscopySingle cell analysisVibrational phenomics

Identifiers

PMID38914839

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.