Evidence map›Paper›PMID 38915480›Full record

ArticlebioRxiv : the preprint server for biology2024

A higher order PUF complex is central to regulation of

Chen Qiu, Sarah L Crittenden, Brian H Carrick, Lucas B Dillard, Stephany J Costa Dos Santos, Venkata P Dandey, Robert C Dutcher, Elizabeth G Viverette, Robert N Wine, Jennifer Woodworth and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Chen QiuEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0000-0003-4294-7537
Sarah L CrittendenDepartment of Biochemistry, University of Wisconsin, Madison, WI 53706, USA.ORCID 0000-0003-3375-9825
Brian H CarrickDepartment of Biochemistry, University of Wisconsin, Madison, WI 53706, USA.ORCID 0000-0003-0139-3582
Lucas B DillardGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0000-0003-4325-8055
Stephany J Costa Dos SantosDepartment of Biochemistry, University of Wisconsin, Madison, WI 53706, USA.ORCID 0000-0002-4147-6756
Venkata P DandeyGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Robert C DutcherEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0000-0002-5144-2111
Elizabeth G ViveretteGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Robert N WineEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0009-0009-3242-5699
Jennifer WoodworthDepartment of Biochemistry, University of Wisconsin, Madison, WI 53706, USA.
Zachary T CampbellDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.ORCID 0000-0002-3768-6996
Marvin WickensDepartment of Biochemistry, University of Wisconsin, Madison, WI 53706, USA.ORCID 0000-0002-0593-5740
Mario J BorgniaGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0000-0001-9159-1413
Judith KimbleDepartment of Biochemistry, University of Wisconsin, Madison, WI 53706, USA.ORCID 0000-0001-5622-2073
Traci M Tanaka HallEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.ORCID 0000-0001-6166-3009

Funding

Structural Studies Of Post-Transcriptional Gene RegulationZIAES050165 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HALL, TRACI M · 2009 to 2025
$45.7M
NIEHS Cryo-EM Core FacilityZICES103326 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BORGNIA, MARIO · 2017 to 2025
$17.0M
FUNCTION OF POLY(A) AND 3'UTRSR01GM050942 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WICKENS, MARVIN P. · 1994 to 2020
$8.3M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Profiling Translation in Nociceptor PlasticityR01NS114018 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Zachary Campbell · 2020 to 2026
$3.2M
Molecular regulation of germline developmentR01GM134119 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KIMBLE, JUDITH · 2019 to 2022
$2.2M
Intramural NIH HHS ZIA ES050165Intramural NIH HHS ZIC ES103326NIGMS NIH HHS R01 GM050942NIGMS NIH HHS R01 GM134119NIH HHS P40 OD010440NINDS NIH HHS R01 NS114018
6 · The paper itself

Abstract

PUF RNA-binding proteins are broadly conserved stem cell regulators. Nematode PUF proteins maintain germline stem cells (GSCs) and, with key partner proteins, repress differentiation mRNAs, including

Indexed as

Caenorhabditis eleganscryogenic electron microscopygermline stem cellsintrinsically disordered regionPUF proteinRNARNA-binding proteinX-ray crystallography

Identifiers

PMID38915480
PMCPMC11195197

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.