Evidence map›Paper›PMID 38915529›Full record

ArticlebioRxiv : the preprint server for biology2024

Endothelial cell Piezo1 promotes vascular smooth muscle cell differentiation on large arteries.

Javier Abello, Ying Yin, Yonghui Zhao, Josh Maurer, Jihui Lee, Cherokee Bodell, Abigail J Clevenger, Zarek Burton, Megan E Goeckel, Michelle Lin and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Javier AbelloDepartment of Cell Biology and Physiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Ying YinDepartment of Cell Biology and Physiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Yonghui ZhaoDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Josh MaurerDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Jihui LeeDepartment of Cell Biology and Physiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Cherokee BodellDepartment of Cell Biology and Physiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Abigail J ClevengerDepartment of Biomedical Engineering, Texas A&M University, College Station, Texas, USA.
Zarek BurtonDepartment of Cell Biology and Physiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Megan E GoeckelDepartment of Cell Biology and Physiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Michelle LinDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Stephanie GraingerDepartment of Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan, USA.ORCID 0000-0001-6889-7174
Carmen M HalabiDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Shreya A RaghavanDepartment of Biomedical Engineering, Texas A&M University, College Station, Texas, USA.ORCID 0000-0002-4631-7762
Rajan SahDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Amber N StratmanDepartment of Cell Biology and Physiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-8111-4186

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Understanding WNT9A/FZD9 Trafficking and SignalingR35GM142779 · NIGMS · VAN ANDEL RESEARCH INSTITUTE · PI GRAINGER, STEPHANIE LAURA · 2021 to 2025
$2.6M
Mechanosensitive mechanisms regulating cellular coordination during tissue morphogenesis and patterningR35GM137976 · NIGMS · WASHINGTON UNIVERSITY · PI STRATMAN, AMBER NICOLE · 2020 to 2024
$2.4M
NCATS NIH HHS UL1 TR002345NIGMS NIH HHS R35 GM137976NIGMS NIH HHS R35 GM142779
6 · The paper itself

Abstract

Vascular stabilization is a mechanosensitive process, in part driven by blood flow. Here, we demonstrate the involvement of the mechanosensitive ion channel, Piezo1, in promoting arterial accumulation of vascular smooth muscle cells (vSMCs) during zebrafish development. Using a series of small molecule antagonists or agonists to temporally regulate Piezo1 activity, we identified a role for the Piezo1 channel in regulating

Indexed as

arterial stabilizationmural cellPiezo1vascular smooth musclezebrafish

Identifiers

PMID38915529
PMCPMC11195244

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.