Evidence map›Paper›PMID 38915613›Full record

ArticlebioRxiv : the preprint server for biology2024

A Path Integral Approach for Allele Frequency Dynamics Under Polygenic Selection.

Nathan W Anderson, Lloyd Kirk, Joshua G Schraiber, Aaron P Ragsdale

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Nathan W AndersonDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Lloyd KirkDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Joshua G SchraiberDepartment of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0002-7912-2195
Aaron P RagsdaleDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0003-0715-3432

Funding

Institutional Training in the Genomic SciencesT32HG002760 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI Qiongshi Lu · 2003 to 2026
$17.7M
NHGRI NIH HHS T32 HG002760
6 · The paper itself

Abstract

Many phenotypic traits have a polygenic genetic basis, making it challenging to learn their genetic architectures and predict individual phenotypes. One promising avenue to resolve the genetic basis of complex traits is through evolve-and-resequence experiments, in which laboratory populations are exposed to some selective pressure and trait-contributing loci are identified by extreme frequency changes over the course of the experiment. However, small laboratory populations will experience substantial random genetic drift, and it is difficult to determine whether selection played a roll in a given allele frequency change. Predicting how much allele frequencies change under drift and selection had remained an open problem well into the 21

Indexed as

diffusion approximationEvolve and resequencepolygenic selectiontransition density

Identifiers

PMID38915613
PMCPMC11195211

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.