Evidence map›Paper›PMID 38915705›Full record

ArticlebioRxiv : the preprint server for biology2024

Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging.

Misbahud Din, Souvik Paul, Sana Ullah, Haoyi Yang, Rong-Guang Xu, Nurul Aisha Zainal Abidin, Allan Sun, Yiyao Catherine Chen, Rui Gao, Bari Chowdhury and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Misbahud DinDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA.
Souvik PaulDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA.
Sana UllahDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA.
Haoyi YangDepartment of Statistics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Rong-Guang XuDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA.
Nurul Aisha Zainal AbidinSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW 2008, Australia.
Allan SunSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW 2008, Australia.
Yiyao Catherine ChenSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW 2008, Australia.
Rui GaoSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW 2008, Australia.
Bari ChowdhuryDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA.
Fangyuan ZhouCoulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.ORCID 0000-0003-0601-4553
Stephenie RogersDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA.
Mariel MillerDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA.
Atreyee BiswasDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA.
Liang HuSchool of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhichao FanDepartment of Immunology, School of Medicine, UConn Health, Farmington, Connecticut 06030, USA.ORCID 0000-0001-5385-9626
Christopher ZahnerDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas 77555, USA.
Jing FanDepartment of Mechanical Engineering, The City University of New York - City College, New York, New York 10031, USA.
Zi ChenDivision of Thoracic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Megan BermanDepartment of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas 77555, USA.
Lingzhou XueDepartment of Statistics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Lining Arnold JuSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW 2008, Australia.
Yunfeng ChenDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA.

Funding

UTMB OAIC Research Education Component (REC)P30AG024832 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI JAMES S. GOODWIN, MD, MELISSA M. MORROW · 2005 to 2026
$26.7M
Collaborative Research: DMS/NIGMS 2: New statistical methods, theory, and software for microbiome dataR01GM152812 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Lingzhou Xue, Xiufan Yu · 2023 to 2026
$1.2M
Inhibiting biomechanical platelet aggregation to prevent arterial thrombosis without compromising hemostasisR00HL153678 · NHLBI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CHEN, YUNFENG · 2022 to 2024
$746k
NHLBI NIH HHS R00 HL153678NIA NIH HHS P30 AG024832NIGMS NIH HHS R01 GM152812
6 · The paper itself

Abstract

Arterial thrombosis, which represents a critical complication of cardiovascular diseases, is a leading cause of death and disability worldwide with no effective bioassay for clinical prediction. As a symbolic feature of arterial thrombosis, severe stenosis in the blood vessel creates a high-shear, high-gradient flow environment that effectively facilitates platelet aggregation towards vessel occlusion even with platelet amplification loops inhibited. However, no approach is currently available to comprehensively characterize the size, composition and platelet activation status of thrombi forming under this biorheological condition. Here, we present a thrombus profiling assay that monitors the multi-dimensional attributes of thrombi forming in conditions mimicking the physiological scenario of arterial thrombosis. Using this platform, we demonstrate that different receptor-ligand interactions contribute distinctively to the composition and activation status of the thrombus. Our investigation into hypertensive and older individuals reveals intensified biomechanical thrombogenesis and multi-dimensional thrombus profile abnormalities, demonstrating a direct contribution of mechanobiology to arterial thrombosis and endorsing the diagnostic potential of the assay. Furthermore, we identify the hyperactivity of GPIbα-integrin α

Identifiers

PMID38915705
PMCPMC11195082

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.