Evidence map›Paper›PMID 38915719›Full record

ArticlebioRxiv : the preprint server for biology2024

Intra-organ cell specific mitochondrial quantitative interactomics.

A A Bakhtina, M D Campbell, B D Sibley, M Sanchez-Contreras, M T Sweetwyne, J E Bruce

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A A BakhtinaUniversity of Washington, Department of Genome Sciences.ORCID 0000-0003-4550-1135
M D CampbellUniversity of Washington, Department of Anesthesiology.
B D SibleyUniversity of Washington, Department of Laboratory Medicine and Pathology.
M Sanchez-ContrerasUniversity of Washington, Department of Laboratory Medicine and Pathology.
M T SweetwyneUniversity of Washington, Department of Laboratory Medicine and Pathology.
J E BruceUniversity of Washington, Department of Genome Sciences.

Funding

SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI PRUSKY, GLEN THOMAS · 1985 to 2021
$29.6M
Mitochondrial Protection to Derive Expanded Aged Renal Glomerular Progenitor CellsK01AG062757 · NIA · UNIVERSITY OF WASHINGTON · PI SWEETWYNE, MARIYA TS'ANA · 2019 to 2023
$619k
Contribution of somatic mitochondrial DNA mutation to the transition from normal aging to Alzheimers diseaseK01AG073470 · NIA · UNIVERSITY OF WASHINGTON · PI Monica Yicette Sanchez-Contreras · 2022 to 2026
$607k
Mitochondrial DNA mutations in the renal cortex to elucidate cell-specific mechanisms of mitochondrial dysfunction in tubules and glomeruliR21DK128540 · NIDDK · UNIVERSITY OF WASHINGTON · PI SANCHEZ-CONTRERAS, MONICA YICETTE, SWEETWYNE, MARIYA TS'ANA · 2021 to 2023
$583k
NIA NIH HHS K01 AG062757NIA NIH HHS K01 AG073470NIA NIH HHS P01 AG001751NIDDK NIH HHS R21 DK128540
6 · The paper itself

Abstract

Almost every organ consists of many cell types, each with its unique functions. Proteomes of these cell types are thus unique too. But it is reasonable to assume that interactome (inter and intra molecular interactions of proteins) are also distinct since protein interactions are what ultimately carry out the function. Podocytes and tubules are two cell types within kidney with vastly different functions: podocytes envelop the blood vessels in the glomerulus and act as filters while tubules are located downstream of the glomerulus and are responsible for reabsorption of important nutrients. It has been long known that for tubules mitochondria plays an important role as they require a lot of energy to carry out their functions. In podocytes, however, it has been assumed that mitochondria might not matter as much in both normal physiology and pathology

Identifiers

PMID38915719
PMCPMC11195139

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.