Evidence map›Paper›PMID 38915855›Full record

SynthesisFrontiers in nutrition2024

High-fat diet-negative impact on female fertility: from mechanisms to protective actions of antioxidant matrices.

Chiara Di Berardino, Urte Barceviciute, Chiara Camerano Spelta Rapini, Alessia Peserico, Giulia Capacchietti, Nicola Bernabò, Valentina Russo, Valentina Gatta, Fani Konstantinidou, Marisa Donato and 1 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chiara Di BerardinoDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Urte BarceviciuteDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Chiara Camerano Spelta RapiniDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Alessia PesericoDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Giulia CapacchiettiDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Nicola BernabòDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Valentina RussoDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Valentina GattaDepartment of Psychological Health and Territorial Sciences, School of Medicine and Health Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Fani KonstantinidouDepartment of Psychological Health and Territorial Sciences, School of Medicine and Health Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Marisa DonatoDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Barbara BarboniDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Excessive calorie intake poses a significant threat to female fertility, leading to hormonal imbalances and reproductive challenges. Overconsumption of unhealthy fats exacerbates ovarian dysfunction, with an overproduction of reactive oxygen species causing oxidative stress, impairing ovarian follicle development and leading to irregular ovulation and premature ovarian failure. Interest in biological matrices with high antioxidant properties to combat diet-related oxidative stress has grown, as they contain various bioactive factors crucial for neutralizing free radicals potentially preventing female reproductive health. This systematic review evaluates the female reproductive impact of biological matrices in mitigating oxidative damages induced by over calory habits and, in particular, high fat diets. Methods: A comparative approach among mammalian models was utilized to interpret literature available data. This approach specifically investigates the antioxidant mechanisms of biological matrices on early and late ovarian folliculogenesis, under physiological and hormone-induced female reproductive cycle. Adhering to the PRISMA 2020 guidelines, only English-language publications from peer-reviewed international indexes were considered. Results: The analysis of 121 publications meeting the inclusion criteria facilitated the identification of crucial components of biological matrices. These components, including carbocyclic sugars, phytonutrients, organosulfur compounds, and vitamins, were evaluated for their impact on ovarian follicle resilience, oocyte quality, and reproductive lifespan. The detrimental effects of oxidative stress on female fertility, particularly exacerbated by high saturated fat diets, are well-documented. Conclusion: Further research is essential to fully exploit the potential of these matrices in enhancing female reproduction and mitigating the effects of diets rich in fatty acids. This requires intensified

Indexed as

antioxidantbiological matrixembryo developmentfolliculogenesishigh-fat dietoocyte qualityovarian health

Identifiers

PMID38915855
PMCPMC11194403

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.