ArticleThe Journal of clinical endocrinology and metabolism2025
Effect of Gestational Diabetes on Fetal Growth Rate and Later Overweight in the Offspring.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human milk composition in women with gestational diabetes mellitus: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Discordance between abdominal circumference and estimated fetal weight in the late third trimester and risk of adverse perinatal outcomes.American journal of obstetrics & gynecology MFM · 2026Article
- Maternal metabolic determinants of accelerated infant weight gain in early life: assessing the combined effects of gestational diabetes and pre-pregnancy overweight.BMC public health · 2026Article
- A novel histopathological insight: caspase-3 and Azan staining reveal placental malformations ameliorated by ethanolic extract of propolis in streptozotocin-induced diabetes during gestation.Journal of molecular histology · 2026Article
- Digital Health-Based Peer Support Ecosystem for Gestational Diabetes Mellitus in Vietnam (VALID II Study): Multistakeholder Cocreation and Pilot Study.Journal of medical Internet research · 2026Article
- Advances in Research on Childhood-Obesity Associated With Gestational Diabetes Mellitus.Journal of diabetes · 2026Review
- Effect of Gestational Diabetes on Fetal Growth Rate and Later Overweight in the Offspring.The Journal of clinical endocrinology and metabolism · 2025Article
- The Role of the Intrauterine Environment in Shaping Childhood and Adolescence Metabolic Outcomes.Metabolites · 2025Review
- Optimizing gestational diabetes diagnostic criteria to predict adverse perinatal outcomes in the United Arab Emirates: The Mutaba'ah Study.Frontiers in endocrinology · 2025Article
- Impact of Gestational Diabetes Mellitus on Fetal Growth and Nutritional Status in Newborns.Nutrients · 2024Review
- Review
- Deciphering DNA Methylation in Gestational Diabetes Mellitus: Epigenetic Regulation and Potential Clinical Applications.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
contextChildren of women with gestational diabetes (GDM) are often born with a higher birthweight and have an increased risk of overweight during childhood. High fetal growth rate is also associated with being overweight in childhood.
objectiveTo examine excessive fetal growth rate as a mediator between GDM and overweight in the offspring.
methodsThis was a longitudinal cohort study, using routinely collected data on children born between 2008 and 2014 in Aarhus, Denmark. Fetal biometrics were extracted from the patient records at Aarhus University Hospital and childhood weight from the health records at Aarhus Municipality Healthcare Service. We calculated growth trajectories for fetuses affected by GDM and for unaffected fetuses using cubic mixed model regression. We extracted individual fetal growth rate and estimated the contributing effect of fetal growth rate on the risk of being overweight in the 5- to 9-year-old offspring.
resultsWe included 6794 mother-child pairs, 295 with GDM. Fetal growth was higher in women with GDM from week 25, and the offspring had an increased risk of being overweight (odds ratio, 2.02 [95% CI, 1.44-2.84]). When adjusting for fetal growth rate in week 28, the effect attenuated by 15%, and to 1.10 (95% CI, 0.76-1.60) when further adjusting for prepregnancy body mass index.
conclusionPregnancies affected by GDM had higher fetal growth rate and the offspring had a higher risk of being overweight at age 5 to 9 years. Fetal growth rate in early third trimester was a mediator of up to 15% of this association, but prepregnancy body mass index contributed strongly as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.