Evidence map›Paper›PMID 38917475›Full record

ArticleBiomacromolecules2024

Membrane Permeability and Responsiveness Drive Performance: Linking Structural Features with the Antitumor Effectiveness of Doxorubicin-Loaded Stimuli-Triggered Polymersomes.

Eliézer Jäger, Peter Černoch, Martina Vragovic, Lindomar Jose Calumby Albuquerque, Vladimir Sincari, Tomáš Heizer, Alessandro Jäger, Jan Kučka, Olga Šebestová Janoušková, Ewa Pavlova and 2 more

Abstract read
In one paragraph

Article in Biomacromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eliézer JägerInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 162 00, Czech Republic.ORCID 0000-0001-9939-2355
Peter ČernochInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 162 00, Czech Republic.
Martina VragovicInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 162 00, Czech Republic.
Lindomar Jose Calumby AlbuquerqueInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 162 00, Czech Republic.ORCID 0000-0003-1443-1795
Vladimir SincariInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 162 00, Czech Republic.ORCID 0000-0002-7379-066X
Tomáš HeizerCenter for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Prague 120 00, Czech Republic.
Alessandro JägerInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 162 00, Czech Republic.
Jan KučkaInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 162 00, Czech Republic.
Olga Šebestová JanouškováInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 162 00, Czech Republic.
Ewa PavlovaInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 162 00, Czech Republic.
Luděk ŠefcCenter for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Prague 120 00, Czech Republic.
Fernando Carlos GiacomelliCentro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo Andre 09280-560, Brazil.ORCID 0000-0002-6872-9354

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The permeability and responsiveness of polymer membranes are absolutely relevant in the design of polymersomes for cargo delivery. Accordingly, we herein correlate the structural features, permeability, and responsiveness of doxorubicin-loaded (DOX-loaded) nonresponsive and stimuli-responsive polymersomes with their in vitro and in vivo antitumor performance. Polymer vesicles were produced using amphiphilic block copolymers containing a hydrophilic poly[

Indexed as

DoxorubicinAcrylamidesAnimalsAntibiotics, AntineoplasticAntineoplastic AgentsCell Line, TumorCell Membrane PermeabilityDrug CarriersHumansHydrogen-Ion ConcentrationMicePolymersReactive Oxygen SpeciesAcrylamidesAntibiotics, AntineoplasticAntineoplastic AgentsDoxorubicinDrug CarriersPolymersReactive Oxygen Species

Identifiers

PMID38917475
PMCPMC11238342

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.