Evidence map›Paper›PMID 38917890›Full record

ArticleToxicology and applied pharmacology2024

An in vitro-in silico workflow for predicting renal clearance of PFAS.

Hsing-Chieh Lin, Courtney Sakolish, Haley L Moyer, Paul L Carmichael, Maria T Baltazar, Stephen S Ferguson, Jason P Stanko, Philip Hewitt, Ivan Rusyn, Weihsueh A Chiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Incorporating new approach methods (NAMs) data in dose-response assessments: The future is now!Journal of toxicology and environmental health. Part B, Critical reviews · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hsing-Chieh LinDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
Courtney SakolishDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
Haley L MoyerDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
Paul L CarmichaelUnilever Safety and Environmental Assurance Centre, Bedfordshire MK44 1LQ, UK.
Maria T BaltazarUnilever Safety and Environmental Assurance Centre, Bedfordshire MK44 1LQ, UK.
Stephen S FergusonDivision of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA.
Jason P StankoDivision of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA.
Philip HewittChemical and Preclinical Safety, Merck Healthcare KGaA, 64293 Darmstadt, Germany.
Ivan RusynDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
Weihsueh A ChiuDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. Electronic address: wchiu@tamu.edu.

Funding

Research Services Supporting the Division of Translational ToxicologyZICES103380 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HOOTH, MICHELLE · 2022 to 2025
$42.8M
Single cell, multi-parametric high throughput platform to classify endocrine disruptor potential of mixturesP42ES027704 · NIEHS · TEXAS A&M UNIVERSITY · PI Ivan Rusyn · 2017 to 2026
$21.2M
Safe and Sustainable Alternatives Research ProgramZIAES103381 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FERGUSON, STEPHEN · 2022 to 2025
$7.0M
Regulatory Science in Environmental Health and ToxicologyT32ES026568 · NIEHS · TEXAS A&M UNIVERSITY · PI Weihsueh A Chiu, Natalie M Johnson · 2016 to 2026
$3.8M
IMSD at Texas A&M University: Initiative for Maximizing Student Diversity in Biomedical SciencesT32GM135748 · NIGMS · TEXAS A&M UNIVERSITY · PI BRINKMEYER-LANGFORD, CANDICE L., CHIU, WEIHSUEH A · 2020 to 2024
$1.2M
EPA RD840032NIEHS NIH HHS P42 ES027704NIEHS NIH HHS T32 ES026568NIGMS NIH HHS T32 GM135748
6 · The paper itself

Abstract

Per- and poly-fluoroalkyl substances (PFAS) have a wide range of elimination half-lives (days to years) in humans, thought to be in part due to variation in proximal tubule reabsorption. While human biomonitoring studies provide important data for some PFAS, renal clearance (CL

Indexed as

Computer SimulationFluorocarbonsKidney Tubules, ProximalModels, BiologicalEnvironmental PollutantsEpithelial CellsHalf-LifeHumansMetabolic Clearance RateRenal EliminationWorkflowEnvironmental PollutantsFluorocarbonsIn vitro-in silico methodMicrophysiological systemPerfluoroalkyl substancesPhysiological-based kidney modelPolyfluoroalkyl substancesRenal clearance

Identifiers

PMID38917890
PMCPMC11585971

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.