Evidence map›Paper›PMID 38918708›Full record

SynthesisBMC neuroscience2024

Diabetes mellitus and risk of incident dementia in APOE ɛ4 carriers: an updated meta-analysis.

Ava Rashtchian, Mohammad Hossein Etemadi, Elham Asadi, Sara Binaei, Mina Abbasi, Maedeh Bayani, Erfan Izadi, Sayedeh-Fatemeh Sadat-Madani, Mahdyieh Naziri, Sahar Khoshravesh and 3 more

RetractedAbstract readMeta-AnalysisRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Ava Rashtchian *Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran.
Mohammad Hossein Etemadi *Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Elham Asadi *Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran.
Sara BinaeiEndocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Mina AbbasiStudent Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Maedeh BayaniStudent Research Committee,, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Erfan IzadiStudent Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Sayedeh-Fatemeh Sadat-MadaniMedical Doctor, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mahdyieh NaziriStudent Research Committee, School of Health, Iran University of Medical Science, Tehran, Iran.ORCID http://orcid.org/0000-0002-2981-0678
Sahar KhoshraveshShahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0002-0823-3701
Mahsa ShiraniStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran.ORCID http://orcid.org/0000-0003-2259-8261
Mahsa Asadi AnarStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran. Mahsa.boz@gmail.com.ORCID http://orcid.org/0000-0002-5772-2472
Niloofar DeraviStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran. Niloofarderavi@sbmu.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimDiabetes raises the risk of dementia, mortality, and cognitive decline in the elderly, potentially because of hereditary variables such as APOE. In this study, we aim to evaluate Diabetes mellitus and the risk of incident dementia in APOE ɛ4 carriers.

methodWe thoroughly searched PubMed (Medline), Scopus, and Google Scholar databases for related articles up to September 2023. The titles, abstracts, and full texts of articles were reviewed; data were extracted and analyzed.

resultThis meta-analysis included nine cohorts and seven cross-sectional articles with a total of 42,390 population. The study found that APOE ɛ4 carriers with type 2 diabetes (T2D) had a 48% higher risk of developing dementia compared to non-diabetic carriers (Hazard Ratio;1.48, 95%CI1.36-1.60). The frequency of dementia was 3 in 10 people (frequency: 0.3; 95%CI (0.15-0.48). No significant heterogeneity was observed. Egger's test, which we performed, revealed no indication of publication bias among the included articles (p = 0.2).

conclusionOverall, diabetes increases the risk of dementia, but further large-scale studies are still required to support the results of current research.

Indexed as

Apolipoprotein E4DementiaDiabetes Mellitus, Type 2HeterozygoteHumansIncidenceRisk FactorsApolipoprotein E4Alzheimer’s diseaseAPOE ɛ4DementiaDiabetes mellitus

Identifiers

PMID38918708
PMCPMC11201872

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.