Evidence map›Paper›PMID 38918984›Full record

ArticleCurrent molecular medicine2025

HGF, HNRPD, and sFLT1 Interfere with the Induction of VEGF in Patients with Severe Psoriasis.

Vladimir Sobolev, Madina Muminova, Olga Zhukova, Elena Denisova, Anna Soboleva, Nikolay Potekaev, Irina Korsunskaya, Alexandre Mezentsev

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Article in Current molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vladimir SobolevLaboratory of Physicochemical and Genetic Problem in Dermatology, Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0003-4779-156X
Madina MuminovaDepartment of Dermatovenerology, Allergology and Cosmetology, Peoples' Friendship University of Russia, "RUDN University", Moscow, Russia.
Olga ZhukovaDepartment of Dermatovenerology, Allergology and Cosmetology, Peoples' Friendship University of Russia, "RUDN University", Moscow, Russia.ORCID 0000-0001-5723-6573
Elena DenisovaLaboratory of Physicochemical and Genetic Problem in Dermatology, Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0002-4887-284X
Anna SobolevaLaboratory of Physicochemical and Genetic Problem in Dermatology, Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0002-9158-1933
Nikolay PotekaevLaboratory of Physicochemical and Genetic Problem in Dermatology, Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0002-9578-5490
Irina KorsunskayaLaboratory of Physicochemical and Genetic Problem in Dermatology, Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0002-6583-0318
Alexandre MezentsevLaboratory of Physicochemical and Genetic Problem in Dermatology, Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia.ORCID 0000-0002-4972-9922

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRestructuring of dermal microcapillaries is one of the hallmarks of plaque psoriasis. To control the proliferation of vascular endothelial cells, vascular endothelial growth factor (VEGF) promotes the remodeling of the existing blood vessels and angiogenesis.

objectiveThis study aimed to explain the lowering protein and mRNA levels of VEGF in lesional skin of patients with severe psoriasis (the Psoriasis Area and Severity Index, PASI > 25).

methodsUsing the method of qPCR, we assessed the expression of VEGF mRNA in lesional and nonlesional psoriatic skin. Using ELISA, we also compared the levels of VEGF in skin homogenates of psoriasis patients and healthy volunteers.

resultsWe found that the exacerbation of psoriasis induced VEGF on mRNA and protein levels 12 and 20 times, respectively. We also confirmed a strong correlation between VEGF and PASI score in patients with PASI < 25. In addition, we showed that several factors, namely HGF, HNRPD, and sFLT1 interfere with the biosynthesis of VEGF in skin lesions of patients with PASI > 25%.

conclusionThus, using VEGF as a biomarker to monitor the disease shall be done cautiously in patients with severe psoriasis.

Indexed as

Hepatocyte Growth FactorPsoriasisVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1AdultBiomarkersFemaleHumansMaleMiddle AgedRNA, MessengerSeverity of Illness IndexSkinBiomarkersFLT1 protein, humanHepatocyte Growth FactorHGF protein, humanRNA, MessengerVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1VEGFA protein, humanHGFHNRPDMARCKSL.PASIpsoriasisPTENsFLT1VEGF

Identifiers

PMID38918984

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.