Evidence map›Paper›PMID 38920658›Full record

ArticleCells2024

CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease.

Erin N Lottes, Feyza Ciger, Shatabdi Bhattacharjee, Emily A Timmins, Benoit Tete, Tommy Tran, Jais Matta, Atit A Patel, Daniel N Cox

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Erin N LottesNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0001-8051-5095
Feyza CigerNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Shatabdi BhattacharjeeNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0003-0850-7319
Emily A TimminsNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Benoit TeteNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Tommy TranNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Jais MattaNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Atit A PatelNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Daniel N CoxNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0001-9191-9212

Funding

Cytoskeletal mechanisms of dendrite arbor shape developmentR01NS086082 · NINDS · GEORGIA STATE UNIVERSITY · PI ASCOLI, GIORGIO A, COX, DANIEL N · 2013 to 2023
$3.1M
MARC Supplement at Georgia State University: Workforce Diversity Through Enhanced MentoringT34GM131939 · NIGMS · GEORGIA STATE UNIVERSITY · PI FRANTZ, KYLE J., GAUCHER, ERIC · 2019 to 2023
$1.7M
Uncovering the Roles of Chaperonin CCT in Neural Health and Disease.F31NS130970 · NINDS · GEORGIA STATE UNIVERSITY · PI LOTTES, ERIN · 2023 to 2023
$41k
Georgia State University 2CI Neurogenomics FellowshipGeorgia State University Brains & Behavior FellowshipGeorgia State University Kenneth W. and Georganne F. Honeycutt FellowshipNIGMS NIH HHS T34 GM131939NIH HHS GM131939NIH HHS NS086082NIH HHS NS130970NINDS NIH HHS F31 NS130970NINDS NIH HHS R01 NS086082
6 · The paper itself

Abstract

The development of cell-type-specific dendritic arbors is integral to the proper functioning of neurons within their circuit networks. In this study, we examine the regulatory relationship between the cytosolic chaperonin CCT, key insulin pathway genes, and an E3 ubiquitin ligase (Cullin1) in dendritic development. CCT loss of function (LOF) results in dendritic hypotrophy in

Indexed as

Cullin ProteinsDendritesDrosophila melanogasterDrosophila ProteinsAnimalsChaperonin Containing TCP-1Huntingtin ProteinLarvaMechanistic Target of Rapamycin Complex 1MicrotubulesSensory Receptor CellsSignal TransductionTranscription FactorsChaperonin Containing TCP-1Cullin 1Cullin ProteinsDrosophila ProteinsHuntingtin ProteinMechanistic Target of Rapamycin Complex 1TORC1 protein complex, DrosophilaTranscription Factorschaperonedendrite developmentDrosophilaE3 ubiquitin ligaseHuntingtinTORC1

Identifiers

PMID38920658
PMCPMC11201622

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.