Evidence map›Paper›PMID 38921458›Full record

ArticleMetabolites2024

Serum Uric Acid, Hypertriglyceridemia, and Carotid Plaques: A Sub-Analysis of the URic Acid Right for Heart Health (URRAH) Study.

Claudia Agabiti Rosei, Anna Paini, Giacomo Buso, Alessandro Maloberti, Cristina Giannattasio, Massimo Salvetti, Edoardo Casiglia, Valerie Tikhonoff, Fabio Angeli, Carlo Maria Barbagallo and 39 more

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In one paragraph

Article in Metabolites, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

49 authors.

Claudia Agabiti RoseiDepartment of Clinical and Experimental Sciences, University of Brescia, and ASST Spedali Civili Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy.ORCID 0000-0002-9664-2408
Anna PainiDepartment of Clinical and Experimental Sciences, University of Brescia, and ASST Spedali Civili Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy.
Giacomo BusoDepartment of Clinical and Experimental Sciences, University of Brescia, and ASST Spedali Civili Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy.
Alessandro MalobertiCardiology IV, "A.De Gasperi's" Department, Niguarda Ca' Granda Hospital, 20162 Milan, Italy.ORCID 0000-0002-2612-6264
Cristina GiannattasioCardiology IV, "A.De Gasperi's" Department, Niguarda Ca' Granda Hospital, 20162 Milan, Italy.
Massimo SalvettiDepartment of Clinical and Experimental Sciences, University of Brescia, and ASST Spedali Civili Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy.ORCID 0000-0001-8101-1374
Edoardo CasigliaStudium Patavinum, Department of Medicine, University of Padua, 35100 Padua, Italy.ORCID 0000-0002-0003-3289
Valerie TikhonoffDepartment of Medicine, University of Padua, 35100 Padua, Italy.ORCID 0000-0001-7846-0101
Fabio AngeliDepartment of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.ORCID 0000-0003-4925-7985
Carlo Maria BarbagalloBiomedical Department of Internal Medicine and Specialistics, University of Palermo, 90100 Palermo, Italy.ORCID 0000-0002-4114-038X
Michele BombelliClinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-8459-711X
Federica CappelliDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0009-0005-4044-2967
Rosario CianciDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-7886-8027
Michele CiccarelliDepartment of Advanced Biomedical Sciences, "Federico II" University of Naples, 80133 Naples, Italy.ORCID 0000-0003-2379-1960
Arrigo Francesco Giuseppe CiceroDepartment Hypertension and Cardiovascular Disease Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-4367-3884
Massimo CirilloDepartment of Public Health, "Federico II" University of Naples, 80133 Naples, Italy.ORCID 0000-0002-6409-3504
Pietro CirilloNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, "Aldo Moro" University of Bari, 70122 Bari, Italy.ORCID 0000-0003-4164-6978
Raffaella Dell'OroClinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Lanfranco D'EliaDepartment of Clinical Medicine and Surgery, "Federico II" University of Naples, 80133 Naples, Italy.ORCID 0000-0002-1782-0211
Giovambattista DesideriDepartment of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences Sapienza, University of Rome, 00161 Rome, Italy.
Claudio FerriDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-3594-2503
Ferruccio GallettiDepartment of Clinical Medicine and Surgery, "Federico II" University of Naples, 80133 Naples, Italy.
Loreto GesualdoNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, "Aldo Moro" University of Bari, 70122 Bari, Italy.
Guido GrassiClinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Guido IaccarinoDepartment of Advanced Biomedical Sciences, "Federico II" University of Naples, 80133 Naples, Italy.ORCID 0000-0002-8997-835X
Luciano LippaItalian Society of General Medicine (SIMG), 67051 Avezzano, Italy.
Francesca MallamaciCNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Reggio Cal Unit, 89124 Reggio Calabria, Italy.
Stefano MasiDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-7591-3686
Maria MasulliDepartment of Clinical Medicine and Surgery, "Federico II" University of Naples, 80133 Naples, Italy.
Alberto MazzaDepartment of Internal Medicine, Santa Maria Della Misericordia General Hospital, AULSS 5 Polesana, 45100 Rovigo, Italy.ORCID 0000-0003-2358-7759
Alessandro MengozziDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Pietro NazzaroDepartment of Precision and Regenerative Medicine and Jonic Area (DiMePRe-J), Neurosciences and Sense Organs, University of Bari Medical School, 70122 Bari, Italy.
Paolo PalatiniStudium Patavinum, Department of Medicine, University of Padua, 35100 Padua, Italy.ORCID 0000-0001-5402-4946
Gianfranco ParatiIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Auxologico Italiano, Department of Cardiology, Institute San Luca Hospital, Piazzale Brescia, 20149 Milan, Italy.ORCID 0000-0001-9402-7439
Roberto PontremoliDepartment of Internal Medicine, University of Genoa, IRCSS Ospedale Policlinico San Martino, 16132 Genova, Italy.ORCID 0000-0003-1238-872X
Fosca Quarti-TrevanoClinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Marcello RattazziDepartment of Medicine-DIMED, University of Padova, Medicina Interna 1° Ca' Foncello University Hospital, 31100 Treviso, Italy.
Gianpaolo ReboldiDepartment of Medical and Surgical Science, University of Perugia, 06100 Perugia, Italy.ORCID 0000-0002-9877-0702
Giulia RivasiDepartment of Geriatric and Intensive Care Medicine, Careggi Hospital, University of Florence, 50121 Florence, Italy.ORCID 0000-0002-2736-2242
Elisa RussoDepartment of Internal Medicine, University of Genoa, IRCSS Ospedale Policlinico San Martino, 16132 Genova, Italy.
Giuliano TocciDepartment of Clinical and Molecular Medicine, University of Rome Sapienza, 00185 Rome, Italy.ORCID 0000-0002-0635-4921
Andrea UngarDepartment of Geriatric and Intensive Care Medicine, Careggi Hospital, University of Florence, 50121 Florence, Italy.
Paolo VerdecchiaHospital S. Maria della Misericordia, 06100 Perugia, Italy.
Francesca ViazziDepartment of Internal Medicine, University of Genoa, IRCSS Ospedale Policlinico San Martino, 16132 Genova, Italy.ORCID 0000-0003-4219-7043
Massimo VolpeDepartment of Clinical and Molecular Medicine, University of Rome Sapienza, 00185 Rome, Italy.ORCID 0000-0002-9642-8380
Agostino VirdisDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Maria Lorenza MuiesanDepartment of Clinical and Experimental Sciences, University of Brescia, and ASST Spedali Civili Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy.ORCID 0000-0002-4007-9441
Claudio BorghiDepartment Hypertension and Cardiovascular Disease Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-8039-8781
Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High levels of serum uric acid (SUA) and triglycerides (TG) might promote high-cardiovascular-risk phenotypes, including subclinical atherosclerosis. An interaction between plaques xanthine oxidase (XO) expression, SUA, and HDL-C has been recently postulated. Subjects from the URic acid Right for heArt Health (URRAH) study with carotid ultrasound and without previous cardiovascular diseases (CVD) (n = 6209), followed over 20 years, were included in the analysis. Hypertriglyceridemia (hTG) was defined as TG ≥ 150 mg/dL. Higher levels of SUA (hSUA) were defined as ≥5.6 mg/dL in men and 5.1 mg/dL in women. A carotid plaque was identified in 1742 subjects (28%). SUA and TG predicted carotid plaque (HR 1.09 [1.04-1.27],

Indexed as

cardiovascular riskcarotid plaquesHDL cholesterolLDL cholesterolserum uric acidtriglycerides

Identifiers

PMID38921458
PMCPMC11205863

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.